|
rs13141190
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
|
rs1448817
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
|
rs10501920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, rs10501920 in CNTN5 was associated with AF (p = 9.4 x 10(-6)) and HF (p = 1.2 x 10(-4)).
|
17903304 |
2007 |
|
rs2549513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six associations yielded p < 10(-5).The lowest p-values for each CVD trait were as follows: major CVD, rs499818, p = 6.6 x 10(-6); major CHD, rs2549513, p = 9.7 x 10(-6); AF, rs958546, p = 4.8 x 10(-6); HF: rs740363, p = 8.8 x 10(-6).
|
17903304 |
2007 |
|
rs499818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six associations yielded p < 10(-5).The lowest p-values for each CVD trait were as follows: major CVD, rs499818, p = 6.6 x 10(-6); major CHD, rs2549513, p = 9.7 x 10(-6); AF, rs958546, p = 4.8 x 10(-6); HF: rs740363, p = 8.8 x 10(-6).
|
17903304 |
2007 |
|
rs740363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six associations yielded p < 10(-5).The lowest p-values for each CVD trait were as follows: major CVD, rs499818, p = 6.6 x 10(-6); major CHD, rs2549513, p = 9.7 x 10(-6); AF, rs958546, p = 4.8 x 10(-6); HF: rs740363, p = 8.8 x 10(-6).
|
17903304 |
2007 |
|
rs199472689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.
|
17997361 |
2007 |
|
rs58912633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation.
|
18339564 |
2008 |
|
rs120074192
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Two gain of function mutations in KCNQ1 subunits (S140G and V141M) have been associated with atrial fibrillation (AF).
|
18599533 |
2008 |
|
rs199472687
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two gain of function mutations in KCNQ1 subunits (S140G and V141M) have been associated with atrial fibrillation (AF).
|
18599533 |
2008 |
|
rs199473324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation.
|
18929244 |
2008 |
|
rs2200733
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.
|
18931155 |
2008 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
|
rs2200733
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
|
rs147750704
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this simulation study was to identify at cell and tissue levels' mechanisms by which increased I(K1) facilitates and perpetuates AF.The Courtemanche et al. human atrial cell action potential (AP) model was modified to incorporate reported changes in I(K1) induced by the Kir2.1 V93I mutation in both heterozygous (Het) and homozygous (Hom) mutant forms.
|
19041665 |
2009 |
|
rs587777339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have identified a homozygous mutation, R391H, in NUP155 that cosegregates with AF, affects nuclear localization of NUP155, and reduces nuclear envelope permeability.
|
19070573 |
2008 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
|
rs2200733
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
|
rs10757278
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The G-allele of both SNPs predicted incident stroke in crude additive models [rs2383207 hazard ratios = 1.25 (95% CI = 1.02-1.53), P = 0.04 and rs10757278 hazard ratios = 1.34 (95% CI = 1.09-1.65), P = 0.006], as well as after adjustment for classical cardiovascular risk factors and after additional adjustment for prevalent and incident coronary events, atrial fibrillation, ischemic heart disease and congestive heart failure.
|
19293724 |
2009 |
|
rs2383207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-allele of both SNPs predicted incident stroke in crude additive models [rs2383207 hazard ratios = 1.25 (95% CI = 1.02-1.53), P = 0.04 and rs10757278 hazard ratios = 1.34 (95% CI = 1.09-1.65), P = 0.006], as well as after adjustment for classical cardiovascular risk factors and after additional adjustment for prevalent and incident coronary events, atrial fibrillation, ischemic heart disease and congestive heart failure.
|
19293724 |
2009 |
|
rs1805127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotypes at the AF-associated loci in KCNE1 (S38G) and SCN5A (H558R) were determined by direct DNA sequencing.
|
19305639 |
2009 |
|
rs1805124
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genotypes at the AF-associated loci in KCNE1 (S38G) and SCN5A (H558R) were determined by direct DNA sequencing.
|
19305639 |
2009 |
|
rs121908591
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, T527M was found in two AF families, and A576V and E610K in two other AF families, respectively.
|
19343045 |
2009 |
|
rs121908593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, T527M was found in two AF families, and A576V and E610K in two other AF families, respectively.
|
19343045 |
2009 |
|
rs1805120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a new genetic variation (rs1805120) in the KCNH2 gene that predisposes Chinese Han individuals to the risk of acquired AF.
|
19490382 |
2009 |