Gene: APC ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation. 10756345

2000
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K polymorphism in APC has been found to predispose to colorectal cancer in Ashkenazi Jews, and has recently been associated with an increased risk for breast cancer in the same population. 10555757

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Furthermore, compared with noncarriers, APC I1307K carriers had increased numbers of adenomas and colorectal cancers per patient (P=.03), as well as a younger age at diagnosis. 9973276

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Our findings support the hypothesis that the I1307K mutation is unique to the Ashkenazi Jews, contributes to tumor predisposition in colorectal cancer, and is unrelated to mismatch repair deficiency. 9869603

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population. 10343885

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis. 9869602

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer. 9679946

1998
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2). 9731533

1998
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462). 9679945

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Interestingly, the I1307K APC polymorphism, associated with an increased risk of colorectal cancer, is also present in this family. 9831355

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2). 9731533

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. 9407954

1997
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. 9288102

1997
dbSNP: rs62619935
rs62619935
APC
0.710 GeneticVariation BEFREE Sequence analysis revealed that a patient with a high level of ASE who did not have a family history of CRC carried a nonsense mutation in APC (p.Arg216X). 21995949

2012
dbSNP: rs62619935
rs62619935
APC
T 0.710 CausalMutation CLINVAR

dbSNP: rs755229494
rs755229494
APC
G 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019
dbSNP: rs121913224
rs121913224
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs121913327
rs121913327
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854573
rs137854573
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854575
rs137854575
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs1400295986
rs1400295986
APC
0.700 GeneticVariation UNIPROT

dbSNP: rs145945630
rs145945630
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs1554085355
rs1554085355
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs397515734
rs397515734
APC
T 0.700 CausalMutation CLINVAR