Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057518775
rs1057518775
KCNJ11
C 0.700 GeneticVariation CLINVAR

dbSNP: rs193922479
rs193922479
HNF4A
T 0.700 GeneticVariation CLINVAR

dbSNP: rs587777732
rs587777732
HNF4A ; MIR3646
T 0.700 CausalMutation CLINVAR

dbSNP: rs886041065
rs886041065
ASXL2
T 0.700 CausalMutation CLINVAR

dbSNP: rs268
rs268
LPL
0.010 GeneticVariation BEFREE Heterozygosity for Asn291-->Ser mutation in the lipoprotein lipase gene in two Finnish pedigrees: effect of hyperinsulinemia on the expression of hypertriglyceridemia. 8732773

1996
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. 10382597

1999
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. 10382597

1999
dbSNP: rs11575937
rs11575937
LMNA
0.030 GeneticVariation BEFREE Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes. 10810087

2000
dbSNP: rs11575937
rs11575937
LMNA
0.030 GeneticVariation BEFREE FPLD was recently discovered to result from mutated LMNA (R482Q; OMIM #150330.0010), which is the gene encoding nuclear lamins A and C. Results from extended pedigrees indicate that dyslipidemia precedes the plasma glucose abnormalities in FPLD subjects with mutant LMNA, and that the hyperinsulinemia is present early in the course of the disease. 11122771

2000
dbSNP: rs11575937
rs11575937
LMNA
0.030 GeneticVariation BEFREE Through the use of focused DNA sequencing of positional candidate genes on chromosome 1q21, we discovered that FPLD results from mutations in LMNA (R482Q; OMIM 150330.0010), which is the gene that encodes nuclear lamins A and C. By stratifying members of extended FPLD pedigrees according to LMNA genotype, we found that hyperinsulinemia is present early in the course of the disease and that dyslipidemia (characterized by high triglycerides and depressed HDL cholesterol) precedes the development of glucose abnormalities. 11136544

2000
dbSNP: rs1799883
rs1799883
FABP2
0.010 GeneticVariation BEFREE These results suggest that the Ala54Thr substitution in the FABP2 gene is associated with increased fat oxidation and hyperinsulinemia in normal Korean men, but these effects are not mediated by an increase in the intestinal fatty acid absorption. 11288045

2001
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. 11334419

2001
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. 11334419

2001
dbSNP: rs1232898090
rs1232898090
PPARA
0.010 GeneticVariation BEFREE The Pro12Ala polymorphism in the PPAR-gamma2 gene has been associated with reduced transcriptional activity in vitro and increased insulin sensitivity in vivo. 11334419

2001
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis. 11684868

2001
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE Among the genetic factors, a polymorphism (Pro12Ala) in the peroxisome proliferator-activated receptor (PPAR) gamma is associated with a reduced risk of type 2 diabetes mellitus and increased insulin sensitivity, primarily that of lipolysis. 11684868

2001
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE Our results suggest that the Pro12Ala polymorphism of the PPARgamma-2 gene promotes peripheral deposition of adipose tissue and increased insulin sensitivity for a given BMI. 12370112

2002
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE Our results suggest that the Pro12Ala polymorphism of the PPARgamma-2 gene promotes peripheral deposition of adipose tissue and increased insulin sensitivity for a given BMI. 12370112

2002
dbSNP: rs137852671
rs137852671
ABCC8
0.020 GeneticVariation BEFREE We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity. 12559865

2003
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes. 12643137

2002
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE A common polymorphism (Pro12Ala) of the adipose tissue-specific gamma 2 isoform is associated with increased insulin sensitivity and decreased risk of developing type 2 diabetes. 12643137

2002
dbSNP: rs80356814
rs80356814
LMNA
0.010 GeneticVariation BEFREE However, unlike the LMNA 1908C/T genetic variation, the MC3R 241G/A genetic variation was significantly associated with hyperleptinemia and huperinsulinemia in obese subjects, and there was evidence of interaction between this polymorphism and fat mass or BMI in predicting hyperinsulinemia. 15636422

2004
dbSNP: rs1801282
rs1801282
PPARG
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women. 15853827

2005
dbSNP: rs1805192
rs1805192
PPARG
0.090 GeneticVariation BEFREE The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women. 15853827

2005
dbSNP: rs148969251
rs148969251
ARHGEF12
0.010 GeneticVariation BEFREE A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo. 16644711

2006