|
rs12970134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs17782313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
rs2943641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies.
|
19734900 |
2009 |
|
rs9402571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM.
|
18985156 |
2008 |
|
rs137852671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have described a dominant heterozygous mutation--E1506K--in the sulfonylurea receptor 1 (SUR1) gene (ABCC8) in a Finnish family, which leads to congenital hyperinsulinaemia due to reduction of K(ATP)-channel activity.
|
12559865 |
2003 |
|
rs137852671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conversely, no E1506K currents were recorded at rest or after metabolic inhibition, as expected for a mutation causing hyperinsulinemia.
|
21617188 |
2011 |
|
rs146695489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Octreotide-induced long QT syndrome in a child with congenital hyperinsulinemia and a novel missense mutation (p.Met115Val) in the ABCC8 gene.
|
24080777 |
2013 |
|
rs2014355
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS associated with reduced measures of serum insulin at 30 min following an oral glucose load (per allele effect (β) = -3.8% (-6.3%;-1.3%), P = 0.003), reduced incremental area under the insulin curve (β = -3.6% (-6.3%;-0.9%), P = 0.009), reduced acute insulin response (β = -2.2% (-4.2%;0.2%), P = 0.03), and with increased insulin sensitivity ISIMatsuda (β = 2.9% (0.5%;5.2%), P = 0.02).
|
21211036 |
2011 |
|
rs9997745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GG homozygotes for rs9997745 had increased MetS risk {odds ratio (OR) 1.90 [confidence interval (CI) 1.15, 3.13]; P = 0.01}, displayed elevated fasting glucose (P = 0.001) and insulin concentrations (P = 0.002) and increased insulin resistance (P = 0.03) relative to the A allele carriers.
|
20176858 |
2010 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of the functional promoter polymorphism rs266729 with lower serum adiponectin and increased insulin resistance in diverse ethnic groups may suggest a causal relationship between adiponectin level and insulin resistance.
|
23826141 |
2013 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.
|
20388053 |
2010 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Gln27Glu polymorphism in β2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis.
|
20738880 |
2010 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated that the T/T genotype of the AGT M235T gene polymorphism was positively related to visceral obesity and hyperinsulinemia in obese Japanese women.
|
16713443 |
2006 |
|
rs148969251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo.
|
16644711 |
2006 |
|
rs886041065
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs225014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects.
|
20566590 |
2010 |
|
rs225017
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.
|
25105294 |
2014 |
|
rs1799883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the Ala54Thr substitution in the FABP2 gene is associated with increased fat oxidation and hyperinsulinemia in normal Korean men, but these effects are not mediated by an increase in the intestinal fatty acid absorption.
|
11288045 |
2001 |
|
rs78311289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The K650Q mutation was confirmed, but in contrast to the previous case, we additionally report findings of hyperinsulinemia.
|
20453470 |
2010 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome.
|
23490278 |
2014 |
|
rs10423928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that schizophrenic patients with the A allele of GIPR rs10423928 are at risk of developing hyperinsulinemia when treated with antipsychotics.
|
21747410 |
2012 |
|
rs121909730
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mitochondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result in fasting and amino acid-induced hypoglycemia in hyperinsulinemia hyperammonemia (HI/HA).
|
25024374 |
2014 |
|
rs121909731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.
|
28911206 |
2017 |
|
rs4629571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association with PCOS was observed.SNP rs4629571 was associated with increased insulin resistance.
|
19327767 |
2010 |
|
rs193922479
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|