|
rs1078499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, the present study was carried out to examine the role of five tagged SNPs viz., g.6147G>A (rs7539020), g.5978A>G (rs2493134); g.6241T>C (rs1078499), g.7781G>T (rs11122577), and g.5855G>A (rs3789678) in the development of hypertension.
|
27398822 |
2016 |
|
rs11122577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, the present study was carried out to examine the role of five tagged SNPs viz., g.6147G>A (rs7539020), g.5978A>G (rs2493134); g.6241T>C (rs1078499), g.7781G>T (rs11122577), and g.5855G>A (rs3789678) in the development of hypertension.
|
27398822 |
2016 |
|
rs1177506410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs1275805226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs148446907
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
|
rs148446907
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition to these polymorphisms, the T(-344)C polymorphism in the promoter of the aldosterone synthase gene (CYP11B2) and the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) are considered candidates for the genetic risk of salt-sensitive hypertension.
|
12924618 |
2003 |
|
rs2004776
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Variation in AGT (rs2004776) was associated with systolic blood pressure (β: 0.42 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=3.8×10(-6)), as well as diastolic blood pressure (P=5.0×10(-8)) and hypertension (P=3.7×10(-7)).
|
21444836 |
2011 |
|
rs2004776
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human <i>AGT</i> (<i>hAGT</i>) gene, are associated with hypertension.
|
31201268 |
2019 |
|
rs2067853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six variants, rs2067853 GG [Odds ratio(95% Confidence Interval) = 1.44(1.17-1.78); p = 0.001], rs7079 [1.49(1.20-1.85); p < 0.0001], rs699 G [1.19(1.08-1.13); p < 0.0001], rs3789679 A [1.51(1.14-1.99); p = 0.004], rs2148582 GG [1.31(1.11-1.55); p = 0.002] and rs5051 TC + CC [1.32(1.13-1.60); p = 0.001] conferred risk for HTN (3521 cases versus 1094 controls).
|
23497386 |
2013 |
|
rs2148582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six variants, rs2067853 GG [Odds ratio(95% Confidence Interval) = 1.44(1.17-1.78); p = 0.001], rs7079 [1.49(1.20-1.85); p < 0.0001], rs699 G [1.19(1.08-1.13); p < 0.0001], rs3789679 A [1.51(1.14-1.99); p = 0.004], rs2148582 GG [1.31(1.11-1.55); p = 0.002] and rs5051 TC + CC [1.32(1.13-1.60); p = 0.001] conferred risk for HTN (3521 cases versus 1094 controls).
|
23497386 |
2013 |
|
rs2493132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension.
|
24015270 |
2013 |
|
rs2493134
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genome-wide association studies have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human <i>AGT</i> (<i>hAGT</i>) gene, are associated with hypertension.
|
31201268 |
2019 |
|
rs2493134
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Hence, the present study was carried out to examine the role of five tagged SNPs viz., g.6147G>A (rs7539020), g.5978A>G (rs2493134); g.6241T>C (rs1078499), g.7781G>T (rs11122577), and g.5855G>A (rs3789678) in the development of hypertension.
|
27398822 |
2016 |
|
rs3789678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In multilocus haplotype analysis, the association between frequencies of the haplotypes and AF risk was showed in AGT gene (rs7539020-rs3789678), compared 'TT' haplotype with the common 'TC' haplotype, adjusted for age, gender, LVEF, LVEDD, LAD and frequency of hypertension and diabetes.
|
25723521 |
2015 |
|
rs3789678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Hence, the present study was carried out to examine the role of five tagged SNPs viz., g.6147G>A (rs7539020), g.5978A>G (rs2493134); g.6241T>C (rs1078499), g.7781G>T (rs11122577), and g.5855G>A (rs3789678) in the development of hypertension.
|
27398822 |
2016 |
|
rs3789679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six variants, rs2067853 GG [Odds ratio(95% Confidence Interval) = 1.44(1.17-1.78); p = 0.001], rs7079 [1.49(1.20-1.85); p < 0.0001], rs699 G [1.19(1.08-1.13); p < 0.0001], rs3789679 A [1.51(1.14-1.99); p = 0.004], rs2148582 GG [1.31(1.11-1.55); p = 0.002] and rs5051 TC + CC [1.32(1.13-1.60); p = 0.001] conferred risk for HTN (3521 cases versus 1094 controls).
|
23497386 |
2013 |
|
rs3889728
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The model for SBP consists of 6 environmental factors (age, BMI, waist circumference, exercise [times per week], parental history of hypertension [either or both]) and 1 SNP (rs7305099); model for DBP consists of 6 environmental factors (weight, drinking, exercise [times per week], TG, parental history of hypertension [either and both]) and 3 SNPs (rs5193, rs7305099, rs3889728).
|
31337952 |
2019 |
|
rs3889728
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The RCC risk for AGT_rs3889728 (AG + AA vs. GG) was modified by hypertension (p interaction = 0.039).
|
24978482 |
2015 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Statistically significant associations with hypertension were identified for the T174M (odds ratio [OR]: 1.19; 95% CI: 1.07 to 1.33; P=0.002) and G-217A (OR: 1.37; 95% CI: 1.17 to 1.59; P=0.00006) polymorphisms.
|
18227406 |
2008 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no statistical association between the T174M polymorphism and hypertension risk in all subjects, in a Han Chinese subgroup or in non-Han Chinese minorities.
|
21881578 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the T174M-T235T genotype was more common in the first quintile group, and showed significant association (P=0.05) with the group that had no family history of hypertension.
|
12113411 |
2002 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The occurrence of the frequent ABCC6 gene mutation c.3421C>T (R1141X) and the hypertension-associated genetic variants T174M and M235T in the angiotensinogen (AGT) gene were determined.
|
16133423 |
2005 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the polymorphic variants of AGT gene-M235T and T174M-show association with hypertension.
|
22148914 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two mutations (T174M and M235T) in the angiotensinogen gene have been reported to be associated with hypertension.
|
7946168 |
1994 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the whole population blood pressure levels and prevalence of high blood pressure did not vary according to T1</span>74M and M235T genotypes.
|
7622852 |
1995 |