|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Statistically significant associations with hypertension were identified for the T174M (odds ratio [OR]: 1.19; 95% CI: 1.07 to 1.33; P=0.002) and G-217A (OR: 1.37; 95% CI: 1.17 to 1.59; P=0.00006) polymorphisms.
|
18227406 |
2008 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no statistical association between the T174M polymorphism and hypertension risk in all subjects, in a Han Chinese subgroup or in non-Han Chinese minorities.
|
21881578 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the T174M-T235T genotype was more common in the first quintile group, and showed significant association (P=0.05) with the group that had no family history of hypertension.
|
12113411 |
2002 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The occurrence of the frequent ABCC6 gene mutation c.3421C>T (R1141X) and the hypertension-associated genetic variants T174M and M235T in the angiotensinogen (AGT) gene were determined.
|
16133423 |
2005 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the polymorphic variants of AGT gene-M235T and T174M-show association with hypertension.
|
22148914 |
2012 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two mutations (T174M and M235T) in the angiotensinogen gene have been reported to be associated with hypertension.
|
7946168 |
1994 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the whole population blood pressure levels and prevalence of high blood pressure did not vary according to T1</span>74M and M235T genotypes.
|
7622852 |
1995 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
So, the aim of current study was to develop efficient low-cost method for genotyping of cardiovascular disease and hypertension associated polymorphisms of AGT (rs4762, rs5051) and CYP11B1 (rs6410).
|
30478747 |
2019 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T and T174M variants, especially the T235 allele, contribute to an increased risk of hypertension in these Chinese patients.
|
20216084 |
2010 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, this study provides no evidence that either allele of M235T or T174M contributes to hypertension in this Chinese population.
|
10024331 |
1999 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To further detect the influence of AGT gene single nucleotide polymorphisms (SNPs) in lead-induced hypertension, two SNPs (rs699 and rs4762) were genotyped in a case-control study including 219 lead-exposed subjects and 393 controls.
|
26818744 |
2016 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Molecular variants (M235T and T174M) in the angiotensinogen (AGT) gene and a mutation in the promoter region that involves the presence of an adenine (A) instead of a guanine (G) 6 bp upstream from the transcription initiation site (G-6A) have been reported to have a positive correlation with hypertension.
|
12051013 |
2002 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a polymorphism in the angiotensinogen gene substituting methionine for threonine (T174M) has been associated with hypertension in nondiabetic populations.
|
8593944 |
1996 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population.
|
23716723 |
2014 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evidence on the effect of salt intake on the interaction between angiotensinogen (AGT) T174M polymorphism and high blood pressure is sparse.
|
15055256 |
2004 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the association among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension status in a sample of Nigerians.
|
9170394 |
1997 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AGT T174M and ACE I/D polymorphisms were not associated with hypertension.
|
9533415 |
1998 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of the study were (i) to assess the distribution of the angiotensin II type 1 receptor (AGTR1) gene 1166A/C polymorphism and two polymorphisms of the angiotensinogen (AGT) gene (Met235Thr and Thr174Met) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent coronary angiography, compared with healthy volunteers; (ii) to determine if there was any correlation between these polymorphisms and risk of STEMI; and (iii) to assess the association of the examined polymorphisms with such classic cardiovascular risk factors as hypertension, diabetes mellitus, obesity (based on a body mass index ≥25 kg/m2), smoking, dyslipidemia, and family history of cardiovascular disease.
|
21657802 |
2011 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics.
|
18497458 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results are to be found in the literature on the relationship between the M235T polymorphism of the angiotensinogen (AGT) gene and hypertension.
|
16755155 |
2006 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association study of G(-6)A, A(-20)C and M235T variants in 111 hypertensives with strong family history and 190 normotensives with no family history showed significant linkage disequilibrium between particular haplotypes, but we could find no association with hypertension.
|
10528248 |
1999 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and hypertension in Chinese.
|
9794717 |
1998 |