|
rs889312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis showed that MAP3K1 rs889312 AC/CC significantly reduced OS of patients with tumors smaller than or equal to 5 cm in size (HR, 3.706; 95% CI: 1.329-10.335, <i>p</i>=0.012), poorly differentiated tumors (HR, 3.002; 95% CI: 1.076-8.377, <i>p</i>=0.036) and intestinal tumors (HR, 4.780; 95% CI: 1.138-20.073, <i>p</i>=0.033).
|
31686841 |
2019 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C3435T genotype was an independent predictive factor of good response in breast (response >50 %, i.e., Sataloff T-A and T-B): OR: 4.6 (95 % CI: 1.3-16.1), p = 0.015, for TT patients versus CT and CC patients.
|
23666532 |
2013 |
|
rs2287622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a trend towards significant association of V444A with CC.
|
21691113 |
2011 |
|
rs3740066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a novel association between the common ABCC2 variant c.3972C>T and cholangiocarcinoma risk.
|
19451719 |
2009 |
|
rs11887534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs3197999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we assessed the primary sclerosing cholangitis-associated variant rs3197999 in the MST1 gene, coding for RON receptor tyrosine kinase ligand macrophage stimulating protein, in a large European cholangiocarcinoma cohort.
|
23422030 |
2013 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF inhibitors showed activity in BRAF V600E mutated cholangiocarcinomas and pancreatic carcinomas in non-first line settings.
|
31221175 |
2019 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF inhibitors showed activity in BRAF V600E mutated cholangiocarcinomas and pancreatic carcinomas in non-first line settings.
|
31221175 |
2019 |
|
rs4938723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MiR-34b/c rs4938723 was associated with ESCC TNM staging, differentiation degree, and lymph node metastasis (LNM) for ES CC patients (all P < 0.05).
|
29270777 |
2019 |
|
rs2072671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For CDA rs2072671 (A>C), AC and CC patients had a lower risk of neutropenia than AA patients (P=0.01, hazard ratio: 0.61, 95% confidence interval: 0.41-0.89).
|
30889042 |
2019 |
|
rs11635252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant decrease was identified in the total cholesterol (TC), triglyceride (TG), and weight in those with CC phenotype compared with those with CT phenotype among the cases with rs11635252 (P < .05).CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism.
|
29979427 |
2018 |
|
rs1126579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs1126580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs2230054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs1194919682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Transforming growth factor beta (TGF-β) mRNA expression was assessed according to T869C polymorphism and CC patients presented a higher TGF-β expression but not significant when compared to other genotypes (p = 0.064).
|
22941282 |
2012 |
|
rs7731017
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
|
28779025 |
2018 |
|
rs4986938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the ESR2 rs4986938 (38 bp 3' of STP) GG genotype was associated with a higher risk of bile duct cancer (OR = 3.3, 95% CI 1.3-8.7) compared with the AA genotype, although this estimate was based on a small number of subjects.
|
20172949 |
2010 |
|
rs9679162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the G<i>ALNT14</i>-rs9679162 'TT' genotype was associated with perineural invasion and lymph node metastasis, as well as unfavorable overall survival in patients with resected cholangiocarcinoma.
|
28588705 |
2017 |
|
rs12979860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
rs12979860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Levels of ISGs and IFNL2/3 mRNAs were lower in IFNL3 rs12979860 CC patients compared with non-CC patients, and in treatment responders, compared with nonresponders.
|
26020282 |
2016 |
|
rs17851045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs17851045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs1003723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer.
|
18296645 |
2008 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated rs2910164 in a large European-based cholangiocarcinoma (CCA) cohort.
|
22893469 |
2012 |
|
rs3024270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, decreased risk of invasive bladder cancer was found in carrying rs3024270 CC patients.
|
29595036 |
2019 |