|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
|
17201138 |
2007 |
|
rs763569821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation.
|
11710692 |
2001 |
|
rs3219476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma.
|
23138270 |
2013 |
|
rs34612342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from patients with HCC (n=48) or cholangiocarcinoma (n=84) compared to non-cancerous controls (n=308) were genotyped for the Y165C and G382D mutations in MYH.
|
16292541 |
2006 |
|
rs36053993
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from patients with HCC (n=48) or cholangiocarcinoma (n=84) compared to non-cancerous controls (n=308) were genotyped for the Y165C and G382D mutations in MYH.
|
16292541 |
2006 |
|
rs3219472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma.
|
23138270 |
2013 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs5275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Differentiation of the type 1 EC is significantly and independently influenced by rs5275 polymorphism. rs5275 CC patients have a lower risk to present a G2-G3 EC.
|
25900875 |
2015 |
|
rs2076310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relative to individuals with the RXR-beta C51T (rs2076310) CC genotype, those having the TT genotype had a 1.6-fold risk for bile duct cancer [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 0.99-2.84], with a more pronounced association among men (OR = 2.30; 95% CI = 1.14-4.65; P interaction = 0.07).
|
18375961 |
2008 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs28929474 was significantly enriched in the cholangiocarcinoma group (4.1 vs. 1.7%; OR 2.46, 95% CI 1.14-5.32; Bonferroni corrected p(c) = 0.036), reinforced by Armitage trend testing (OR 2.53; p(c) = 0.032).
|
21138453 |
2011 |
|
rs8004738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the 'common' Z and S alleles as well as the promoter variant rs8004738 for association with cholangiocarcinoma.
|
21138453 |
2011 |
|
rs761937143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-generation sequencing detected mutations at p.Q61H (c.183A>C) of KRAS and p.E545K (c.1633G>A) of PIK3CA, keeping in line with similarity to conventional cholangiocarcinoma.
|
30591492 |
2019 |
|
rs3769839
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
|
28779025 |
2018 |
|
rs7903146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs7903146 C>T polymorphism appeared to modulate the risk of MACE: 5-year prevalence was 0.8% in CC patients, 7.2% in CT patients and 9.7% in TT patients (P<.001).
|
28299838 |
2017 |
|
rs2289278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In children sensitized to certain allergens, a genetic predisposition (rs2289278 genotype CC) significantly increased the risk of AD.
|
26712523 |
2016 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped five non-synonymous single-nucleotide polymorphisms of three genes, including the human homolog of the 8-oxoguanine glycosylase 1 Ser326Cys, X-ray repair cross-complementing protein 1 Arg194Trp, Arg280His and Arg399Gln and poly (adenosine diphosphate ribose) polymerase 1 Val762Ala in 87-94 matched case-control pairs, and examined relations between those polymorphisms and the risk of cholangiocarcinoma.
|
24049014 |
2013 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped five non-synonymous single-nucleotide polymorphisms of three genes, including the human homolog of the 8-oxoguanine glycosylase 1 Ser326Cys, X-ray repair cross-complementing protein 1 Arg194Trp, Arg280His and Arg399Gln and poly (adenosine diphosphate ribose) polymerase 1 Val762Ala in 87-94 matched case-control pairs, and examined relations between those polymorphisms and the risk of cholangiocarcinoma.
|
24049014 |
2013 |
|
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped five non-synonymous single-nucleotide polymorphisms of three genes, including the human homolog of the 8-oxoguanine glycosylase 1 Ser326Cys, X-ray repair cross-complementing protein 1 Arg194Trp, Arg280His and Arg399Gln and poly (adenosine diphosphate ribose) polymerase 1 Val762Ala in 87-94 matched case-control pairs, and examined relations between those polymorphisms and the risk of cholangiocarcinoma.
|
24049014 |
2013 |
|
rs2106261
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, neutrophil/lymphocyte (N/L) ratio, C-reactive protein (CRP), and interleukin-6 (IL-6) expression levels were lower in PAF patients with the ZFHX3 SNP rs2106261 minor allele (TT+TC) than in CC patients (N/L ratio: CC 2.22 ± 0.08, TT+TC 1.98 ± 0.06, p = 0.018; CRP: CC 0.103 ± 0.009 mg/dl, TT+TC 0.076 ±0.007 mg/dl, p = 0.016; IL-6: CC 60.3 ± 3.0 pg/ml, TT+TC 52.8 ± 2.3 pg/ml, p = 0.04).
|
30180182 |
2018 |
|
rs2266788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, homozygous risk allele of rs2266788 (CC) significantly associated with risk of MI and UA in patients of chronic stable angina (CSA) patients.
|
29309886 |
2018 |