|
rs3197999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we assessed the primary sclerosing cholangitis-associated variant rs3197999 in the MST1 gene, coding for RON receptor tyrosine kinase ligand macrophage stimulating protein, in a large European cholangiocarcinoma cohort.
|
23422030 |
2013 |
|
rs3219472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma.
|
23138270 |
2013 |
|
rs3219476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYH rs3219476 and rs3219472 polymorphisms and risk of cholangiocarcinoma.
|
23138270 |
2013 |
|
rs1194919682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Transforming growth factor beta (TGF-β) mRNA expression was assessed according to T869C polymorphism and CC patients presented a higher TGF-β expression but not significant when compared to other genotypes (p = 0.064).
|
22941282 |
2012 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated rs2910164 in a large European-based cholangiocarcinoma (CCA) cohort.
|
22893469 |
2012 |
|
rs11887534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs2287622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a trend towards significant association of V444A with CC.
|
21691113 |
2011 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs28929474 was significantly enriched in the cholangiocarcinoma group (4.1 vs. 1.7%; OR 2.46, 95% CI 1.14-5.32; Bonferroni corrected p(c) = 0.036), reinforced by Armitage trend testing (OR 2.53; p(c) = 0.032).
|
21138453 |
2011 |
|
rs8004738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the 'common' Z and S alleles as well as the promoter variant rs8004738 for association with cholangiocarcinoma.
|
21138453 |
2011 |
|
rs4986938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the ESR2 rs4986938 (38 bp 3' of STP) GG genotype was associated with a higher risk of bile duct cancer (OR = 3.3, 95% CI 1.3-8.7) compared with the AA genotype, although this estimate was based on a small number of subjects.
|
20172949 |
2010 |
|
rs3740066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe a novel association between the common ABCC2 variant c.3972C>T and cholangiocarcinoma risk.
|
19451719 |
2009 |
|
rs1003723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer.
|
18296645 |
2008 |
|
rs1126579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs1126580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs2076310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relative to individuals with the RXR-beta C51T (rs2076310) CC genotype, those having the TT genotype had a 1.6-fold risk for bile duct cancer [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 0.99-2.84], with a more pronounced association among men (OR = 2.30; 95% CI = 1.14-4.65; P interaction = 0.07).
|
18375961 |
2008 |
|
rs2230054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.
|
18676870 |
2008 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
|
17201138 |
2007 |
|
rs34612342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from patients with HCC (n=48) or cholangiocarcinoma (n=84) compared to non-cancerous controls (n=308) were genotyped for the Y165C and G382D mutations in MYH.
|
16292541 |
2006 |
|
rs36053993
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from patients with HCC (n=48) or cholangiocarcinoma (n=84) compared to non-cancerous controls (n=308) were genotyped for the Y165C and G382D mutations in MYH.
|
16292541 |
2006 |
|
rs763569821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation.
|
11710692 |
2001 |