rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII.
|
8024269 |
1994 |
rs1035071612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD.
|
9633759 |
1998 |
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported.
|
11041283 |
2000 |
rs1369330655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD).
|
11304834 |
2001 |
rs17571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD).
|
11304834 |
2001 |
rs63750207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No pathogenic mutations were found, but a rare non-conservative single-nucleotide polymorphism was detected in the PSEN2 gene (P334R) in a large kindred with familial late-onset AD.
|
11803125 |
2002 |
rs1799999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, in the dominant genetic model a marginally significant association in genotype frequencies between the Asp905Tyr PPP1R3 polymorphism and AD was observed (genotypes: OR 1.85, 95% CI 1.03 to 3.30, p = 0.04; alleles: OR 1.68, 95% CI 0.98 to 2.88, p = 0.06).
|
12185156 |
2002 |
rs3730089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis using the recessive genetic model showed significant differences in genotype and allelic frequencies between the AD group and normal controls (genotypes: odds ratio (OR) 2.09, 95% confidence interval (CI) 1.17 to 3.74, p = 0.01; alleles: OR 1.99, 95% CI 1.17 to 3.40, p = 0.01) for the Met326Ile PIK3R1 polymorphism that were female specific.
|
12185156 |
2002 |
rs764929617
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Compared to E3/3 and E3/2 genotypes, the risk of developing AD associated with the genotypes carrying the e(*)4 allele, the well-established risk allele for AD onset, was observed to be high (OR=3.16; 95% CI=1.62-6.20; P=0.0009), but the risk associated with genotypes carrying the Leu28-->Pro mutation was higher still (OR=10.95; 95% CI=1.25-95.75; P=0.015).
|
12498968 |
2003 |
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease.
|
12618290 |
2003 |
rs7493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
|
14741412 |
2004 |
rs1799864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD.
|
15488313 |
2004 |
rs766662990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD.
|
15488313 |
2004 |
rs1805054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that the HTR6 polymorphism C267T possibly involved in the susceptibility to LOAD as an APOE epsilon4-allele independent risk factor of LOAD.
|
15531082 |
2004 |
rs759223338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that BACE1 gene polymorphism C7</span>86G might act as an APOE epsilon4 allele-dependent risk factor for developing LOAD in Chinese.
|
15784960 |
2005 |
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies.
|
15843069 |
2005 |
rs746682028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies.
|
15843069 |
2005 |
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies.
|
15843069 |
2005 |
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease.
|
16055944 |
2005 |
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data further support a role for innate immunity in neurodegeneration and give the first evidence that the TLR4 Asp299Gly variant may be protective toward the development of LOAD.
|
16157451 |
2006 |
rs754203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To find new data to contribute to the evaluation of whether the presence of the T allele in the polymorphic site rs754203 of the CYP46A1 gene leads to a greater risk of developing mild cognitive impairment (MCI) and LOAD.
|
16340204 |
2006 |
rs1051338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin.
|
16730122 |
2006 |
rs2297472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin.
|
16730122 |
2006 |
rs2029721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003).
|
16832079 |
2006 |
rs4877365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets).
|
16847012 |
2006 |