|
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Furthermore, DTC risk was positively associated with the number of copies in the minor allele (A) of rs965513 among people who consumed less iodine than the median.
|
27610545 |
2016 |
|
rs965513
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
|
25879635 |
2015 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Additionally, our results support the protective role of Arg194Trp polymorphism in developing PTC, and show evidence of an association between Arg399Gln polymorphism and decreased risk of DTC in mixed population.
|
23717668 |
2013 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Multivariate analysis demonstrated an increased risk of DTC for the Arg194Trp heterozygous polymorphic (CT) genotype (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 0.9-2.1).
|
19191745 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.
|
24175846 |
2013 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Polymorphisms of XRCC1 (rs25487, rs1799782) and XRCC3 (rs861539), may play a critical role in DTC development and progression.
|
26938431 |
2016 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This meta-analysis arrives at a conclusion that the XRCC1 (Arg399Gln, Arg194Trp, Arg280His) polymorphisms appear to confer no risk for DTC.
|
25086624 |
2014 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Overall, no association of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms with differentiated thyroid carcinoma risk was found.
|
23872202 |
2013 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our results suggest that XRCC1 Arg399Gln polymorphism is not associated with differentiated thyroid carcinoma risk, while a decreased risk is observed among Caucasian population.
|
23872202 |
2013 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The combined results of the relevant studies exhibited that no significant associations with DTC risk were demonstrated for polymorphisms in XRCC1 Arg399Gln, Arg194Trp and Arg280His in all genetic models.
|
25086624 |
2014 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Multivariate analysis demonstrated a decreased risk of DTC for the Arg399Gln homozygous polymorphic (AA) genotype (OR: 0.5, 95% CI: 0.3-0.8) and the polymorphic (A) allele (OR: 0.7, 95% CI: 0.5-1.0).
|
19191745 |
2009 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians.
|
24175846 |
2013 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Additionally, our results support the protective role of Arg194Trp polymorphism in developing PTC, and show evidence of an association between Arg399Gln polymorphism and decreased risk of DTC in mixed population.
|
23717668 |
2013 |
|
rs25487
|
|
|
0.060 |
GeneticVariation |
BEFREE |
SNP of rs25487 was linked with a 53% decrease in DTC risk (OR: 0.47; 95%CI: 0.268-0.82; P = 0.01).
|
26938431 |
2016 |
|
rs944289
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The NKX2-1 rs944289 SNP, however, appears to play a secondary role in the development of DTC in the German population.
|
24325646 |
2014 |
|
rs944289
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Significant association with DTC risk was found for rs944289 near NKX2-1 (OR per A allele = 1.6, 95% CI: 1.2-2.1), and three polymorphisms near or within FOXE1, namely rs965513 (OR per A allele = 1.7, 95% CI: 1.2-2.3), rs1867277 in the promoter region of the gene (OR per A allele = 1.5, 95% CI: 1.1-1.9) and the poly-alanine tract expansion polymorphism rs71369530 (OR per Long Allele = 1.8, 95% CI: 1.3-2.5), only the 2 latter remaining significant when correcting for multiple tests.
|
25879635 |
2015 |
|
rs944289
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role in mortality of patients has not been established.
|
26490305 |
2016 |
|
rs944289
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis revealed that common variations of FOXE1 (rs965513, rs944289 and rs1867277) were risk factors associated with increased DTC susceptibility.
|
29788924 |
2018 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians.
|
24175846 |
2013 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The combined results of the relevant studies exhibited that no significant associations with DTC risk were demonstrated for polymorphisms in XRCC1 Arg399Gln, Arg194Trp and Arg280His in all genetic models.
|
25086624 |
2014 |
|
rs25489
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that Arg280His polymorphism might contribute to the susceptibility of DTC among Caucasians, whereas it might provide protective effects in Asians against the risk of DTC.
|
23717668 |
2013 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer.
|
25835179 |
2015 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, in this study, we analyzed the associations of intron 3 Ins16bp and exon 4 Arg72Pro polymorphisms, as well as their combined genotypes and haplotypes with the risk of differentiated thyroid carcinoma in Iranian-Azeri patients.
|
25410025 |
2015 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, in this study, we analyzed the associations of intron 3 Ins16bp and exon 4 Arg72Pro polymorphisms, as well as their combined genotypes and haplotypes with the risk of differentiated thyroid carcinoma in Iranian-Azeri patients.
|
25410025 |
2015 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significant association of TP53 Arg72Pro polymorphism in susceptibility to differentiated thyroid cancer.
|
25835179 |
2015 |