|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients.
|
21362310 |
2011 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We examined whether genotype at the lead CAD-associated single nucleotide polymorphism (rs1333049) in 9p21 was associated with: 1) basal levels of IFN-I in plasma from 148 healthy male subjects; 2) induction of IFN-I by Toll-like receptor stimulants in peripheral blood mononuclear cells of 60 healthy volunteers assessed by enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21 CAD risk region in reporter assays.
|
23933542 |
2013 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
rs4977574
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
rs11556924
|
|
|
0.840 |
GeneticVariation |
BEFREE |
These findings extend the genetic association between rs11556924 and coronary artery disease risk by characterizing its effects on the encoded protein, NIPA.
|
28115489 |
2017 |
|
rs11556924
|
|
|
0.840 |
GeneticVariation |
BEFREE |
A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals.
|
24286297 |
2013 |
|
rs11556924
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The CAD-associated locus 7q32.2 is unusual in that the lead variant, rs11556924, is not in strong linkage disequilibrium with any other variant and introduces a coding change in ZC3HC1, which encodes NIPA.
|
27226629 |
2016 |
|
rs11556924
|
|
|
0.840 |
GeneticVariation |
BEFREE |
In the present study, we aimed to examine the role of two single-nucleotide polymorphisms (SNPs), rs3825807 and rs11556924, located in the ADAMTS7 and ZC3HC1 genes, respectively, associated with CAD in published GWASs in European populations and their possible contribution to the development of coronary atherosclerosis and cerebral LA atherosclerosis in a case-control study of an the Iranian population.
|
31679296 |
2019 |
|
rs2891168
|
|
|
0.820 |
GeneticVariation |
BEFREE |
A genomic region on chromosome 9p21 has been identified as closely associated with increased susceptibility to coronary artery disease (CAD) and to type 2 diabetes (T2D) although the evidence suggests that the genetic variants within chromosome 9p21 that contribute to CAD are different from those that contribute to T2D.We carried out an association case-control study in an Italian population to test the association between two single nucleotide polymorphisms (SNPs) on the 9p21 locus, rs2891168 and rs10811661, previously reported by the PROCARDIS study, and respectively myocardial infarction (MI) and T2D.
|
20403154 |
2010 |
|
rs2891168
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Two CAD- and aneurysm-associated SNPs (rs10757274 and rs2891168) and one T2D-associated SNP (rs1081161) within the 9p21.3 region were genotyped.
|
19019192 |
2009 |
|
rs974819
|
|
|
0.820 |
GeneticVariation |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
rs974819
|
|
|
0.820 |
GeneticVariation |
BEFREE |
A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect.
|
22704460 |
2012 |
|
rs10947789
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Two variants were nominally associated with several indices; for rs10947789 (KCNK5), the adjusted geometric mean was 2% higher for MPV (95% confidence interval: 1-2%, p=0.002), 6% for IPC (0-12%, p=0.033), and 9% for IPF (3-16%, p=0.004) per CAD risk allele.
|
28865245 |
2017 |