|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
|
18390844 |
2008 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians.
|
23167333 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma.
|
20886596 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that Arg72Pro polymorphism in a WT p53 context may act as a primary driver of epigenetic changes in HCC.
|
25889455 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results.
|
28885338 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows that the Pro/Pro genotype of the p53 Arg72Pro polymorphism is associated with increased risk of HCC development in this Turkish population (OR = 3.20, 95% CI: 1.24-8.22, P = 0.02).
|
21607615 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population.
|
15633234 |
2005 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CG and GG genotypes in rs1042522 and heterozygote and homozygote in rs2279744 were significantly associated with an elevated risk of HCC.
|
25412941 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population.
|
20309940 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC.
|
24376578 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs1043210477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the role of common variation in three polymorphic genes (MnSOD Ala-9Val, GPX1 Pro198Leu and CAT -262 C > T) coding for antioxidant defence enzymes in modulating individual susceptibility to hepatocellular carcinoma (HCC) using a case-control study (cases = 96 and controls = 222).
|
19929244 |
2010 |
|
rs1044250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In human embryonic kidney 293 and human hepatoma 7 cells compared with wild type, E40K and T266M showed significantly altered synthesis and secretion, respectively.
|
20829508 |
2010 |
|
rs1045411
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that the T-C-T haplotype (rs1045411-rs2249825-rs1415125) in HMGB1 gene was associated with a 2.47-fold (95% CI: 1.41-4.34; P = 0.002) increased risk of hepatocellular carcinoma compared with the commonest C-C-T haplotype after adjustment.
|
28187002 |
2017 |
|
rs1045411
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed that HMGB1 SNP rs1045411 with CT or at least one T alleles has lower risk of HCC than wild-type (CC) carriers.
|
27076788 |
2016 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.
|
23109454 |
2013 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
C1236T genotype may predict changes in pathological features of patients with HCC to a certain extent, and C3435T SNP can be used as one of the prognostic factors of HCC.
|
30779721 |
2019 |
|
rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1047781
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study strongly implicates the polymorphic locus rs1047781 of <i>FUT2</i> as being associated with HCC development.
|
28824326 |
2017 |
|
rs1047840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data shows that the Lys/Lys genotype of the Exo 1 K589E polymorphism is associated with increased risk of HCC development in this Turkish population [odds ratio (OR) = 2.15, 95% confidence interval (CI): 1.13-4.09, P = 0.02].
|
22205538 |
2012 |
|
rs1047972
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers.
|
29333101 |
2018 |
|
rs1047972
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrary, no significant association was found between Val57Ile and HBV-related HCC occurrence.
|
28903390 |
2017 |
|
rs10484561
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |