|
rs10485505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In current study, conducted a genetic association study together with epidemiological follow-up study to delineate the role of circ-ITCH in the development and progression of HCC. we found rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1×10-3) and rs4911154 (adjusted OR =1.27; 95% CI=1.14-1.43; P value =3.7×10-5) were significantly associated with increased HCC risk.
|
28636993 |
2017 |
|
rs1048638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CA9 expression levels were also correlated with miR-34a levels and rs1048638 genotypes in HCC patients. rs1048638 influences HCC risk and progression through effects on miR-34a-targeted CA9 expression in HCC.
|
28667334 |
2017 |
|
rs104886003
|
|
|
0.720 |
GeneticVariation |
BEFREE |
PIK3CA missense mutations were found in one of 11 intrahepatic CCA (E545K, 9%), one of 23 gallbladder carcinomas (E542K, 4%), and one of 50 hepatocellular carcinomas (H1047R, 2%).
|
18181165 |
2008 |
|
rs104886003
|
|
C |
0.720 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104886003
|
|
A |
0.720 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104886003
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Similarly, in human HCC cell lines, silencing of SGK3 reduced PIK3CA(E545K</span>) -but not PIK3CA(H1047R)- induced accelerated tumor cell proliferation.
|
30975125 |
2019 |
|
rs104894226
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894226
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894228
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894228
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894229
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894229
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs104894230
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs1049112
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, AG and GA haplotypes of 2 CCL4 SNPs (rs1049112 and rs171915) also reduced the risks for HCC by 0.025 and 0.515 fold, respectively.
|
28824325 |
2017 |
|
rs10491121
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the A/G homozygotes of CCL4 rs10491121 polymorphism reduced the risks for HCC.
|
28824325 |
2017 |
|
rs1049334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the linkage disequilibrium of CAV1 polymorphisms was analyzed by Haploview.The AG genotype and A allele of rs1049334 showed significantly higher frequency in HCC patients than that of chronic HBV patients and the healthy controls (P < .05); so their carriage obviously increased the susceptibility to HBV-related HCC, irrespective of the fact whether individuals were infected with hepatitis B virus or not (AG vs GG: OR 1.958, 95% CI 1.050-3.650, OR 1.899, 95% CI 1.034-3.487; A vs G: OR 1.667, 95% CI 1.033-2.689, OR 1.777, 95% CI 1.103-2.863).
|
29049173 |
2017 |
|
rs1049606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although no significant association was observed between the polymorphisms and HCC outcome among HBV patients, one common polymorphism in the 5'-untranslated region (that is, rs1049606) and the most common haplotype (CCND-ht1 [T-C-T-A-T]), however, were significantly associated with HBV clearance (odds ratio=0.69, P=0.0002, Pcorr=0.001 and odds ratio=1.37, P=0.0009, Pcorr=0.004, respectively).
|
20414251 |
2010 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC).
|
26990426 |
2016 |
|
rs10514231
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bioinformatics analyses showed that allele C of ATG10 rs10514231 was significantly correlated with higher expression of ATG10 gene in both HCC tissues and normal liver tissues.
|
31340167 |
2019 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results showed that, for the two polymorphisms (337 T > C and 416A > G) of EPHX1 gene, neither allele frequency nor genotype distributions were associated with risk for HCC in all genetic models (all P > 0.05).
|
23955801 |
2014 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A meta-analysis was performed to examine the association between Tyr113His and His139Arg mEH polymorphism and susceptibility to HCC.
|
23451147 |
2013 |
|
rs1051740
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Polymorphic forms of the human EPHX gene have been described that vary in enzymatic activity, and one, Tyr113His, has been associated with hepatocellular carcinoma susceptibility.
|
8944076 |
1996 |
|
rs1051792
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KIR2DL2-HLA-C1 (OR = 2.75; 95% confidence interval: 1.21-6.21, <i>P</i> = 0.015) and rs1051792 (OR = 2.48; 95% confidence interval: 1.23-4.98, <i>P</i> = 0.011) were independently associated with HCC development in younger patients.
|
29731972 |
2018 |
|
rs10519613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.
|
29162948 |
2017 |
|
rs1052133
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The data showed that the hOGG1 Cys326Cys and Ser326Cys genotypes were associated with increase in HCC risk.
|
22565339 |
2012 |