|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the stratified analyses for Ser217Leu polymorphism, there was significantly increased prostate cancer risk in Asian and Caucasian populations, and studies using sporadic and familial prostate cancer cases.
|
20231859 |
2010 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele.
|
18823818 |
2008 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested.
|
15981205 |
2005 |
|
rs486907
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported.
|
15534086 |
2004 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although no difference in allele frequency at Ser217Leu between patients with PCa and controls has been reported in a Western population, this polymorphism is a potential indicator of PCa risk in Japanese men and it should be examined in other ethnic groups.
|
12949798 |
2003 |
|
rs4792311
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population.
|
11507049 |
2001 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A rare recurrent missense variant in HOXB13 (rs138213197/G84E) was recently reported to be associated with hereditary prostate cancer.
|
25595936 |
2015 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Men with the HOXB13 G84E variant had a 4.51-fold higher relative risk of PCa compared with non-carriers (95 % CI 3.28-6.20).
|
24026887 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A rare but recurrent missense mutation (G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer.
|
22841674 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
rs138213197
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We evaluated the G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer.
|
22714738 |
2012 |