|
rs2280381
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs17445836 and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (ATA) in AITD.
|
25989711 |
2015 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses were conducted on the associations between AITD and the -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD.
|
27500787 |
2016 |
|
rs2276886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we first reported that the polymorphisms in IL8, RANTES and MIG genes are associated with the development of AITD, and that the MIG rs2276886 AG genotype is associated with the intractability of GD.
|
27245471 |
2016 |
|
rs2276886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the association between functional polymorphisms in genes encoding some chemokines and the pathogenesis of Autoimmune thyroid disease (AITD), we genotyped IL8 -251T/A, Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES) - 403G/A, -28C/G, MIG rs2276886G/A, IP10 -1596C/T, Monocyte Chemoattractant Protein1 (MCP1) - 2518G/A and IL16 -295T/C polymorphisms.
|
27245471 |
2016 |
|
rs2900180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele analysis found that T allele of rs4836834, G allele of rs10760130, A allele of rs10818488, T allele of rs2239658 and T allele of rs2900180 were significantly higher in GD and AITD patients.
|
26699338 |
2016 |
|
rs370711144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the association between functional polymorphisms in genes encoding some chemokines and the pathogenesis of Autoimmune thyroid disease (AITD), we genotyped IL8 -251T/A, Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES) - 403G/A, -28C/G, MIG rs2276886G/A, IP10 -1596C/T, Monocyte Chemoattractant Protein1 (MCP1) - 2518G/A and IL16 -295T/C polymorphisms.
|
27245471 |
2016 |
|
rs7514229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age.
|
27556446 |
2016 |
|
rs1179251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
|
28839453 |
2017 |
|
rs2048722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum levels of TPOAb were significantly higher in AITD patients with TPO rs2071400 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0295), and were also significantly higher in AITD patients with TPO rs2048722 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0056).
|
28845025 |
2017 |
|
rs2071400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum levels of TPOAb were significantly higher in AITD patients with TPO rs2071400 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0295), and were also significantly higher in AITD patients with TPO rs2048722 T carriers (CT + TT genotypes) than in those with the CC genotype (p=0.0056).
|
28845025 |
2017 |
|
rs2227478
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
|
28839453 |
2017 |
|
rs28665122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Major alleles in rs6865453 of SELENOP, rs713041, rs2074451, rs3746165 of GPX4 decreased while the major allele C in rs28665122 of SELENOS increased in AITD patients than in the control.
|
28499373 |
2017 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2618431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, compared with that in female controls, allele G of rs2618431 was increased in the female AITD patients.
|
30351170 |
2018 |
|
rs4840568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele A of rs4840568 linked to the susceptibility of the AITD teenagers.
|
30351170 |
2018 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The overall results indicated that <i>VDR</i> rs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD.
|
29765404 |
2018 |
|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> This meta-analysis showed a significant association between <i>STAT4</i> rs7574865 polymorphism and AITD susceptibility.
|
30666271 |
2018 |
|
rs7975232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the present study suggested that <i>VDR</i> rs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk.
|
29765404 |
2018 |
|
rs1061502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs1131665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs12492609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the allele T of rs12492609 in <i>TMEM39A</i> was associated with AITD and Hashimoto's thyroiditis (HT) (<i>p</i> = 0.023; <i>p</i> = 0.028 respectively).
|
31553233 |
2019 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |