|
Acoustic Neuroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas.
|
20600642 |
2010 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A series of 120 biopsies from benign (verruca vulgaris and keratoacanthoma), premalignant (actinic keratosis and extragenital Bowen's disease) and malignant (squamous cell carcinoma) skin lesions were studied immunohistochemically for the expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67.
|
10429981 |
1999 |
|
Acute Erythroblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpressed p21waf1/cip1 enhanced SP-B induction of the apoptosis of the human erythroleukemia leukemia cell line K562 which is less susceptible to SP-B than NALM-6 cells.
|
22684370 |
2012 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, stable lentiviral p21(WAF1) silencing in the BCP-ALL Nalm-6 cell line accelerated PS externalization and cell death following exposure to etoposide and vorinostat, supporting previous findings.
|
26506264 |
2015 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Although we were unable to link Waf-1 RNA expression with p53 status in childhood ALL, our data show potential p53 inactivation by multiple mechanisms in a large percentage of these patients and demonstrate that these alterations can be detected at diagnosis.
|
8562942 |
1996 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Complementary DNA (cDNA) microarray analysis suggested that CDKN1A might govern the drug responsiveness of ALL cell lines in a TP53-independent manner.
|
24382688 |
2014 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia.
|
11895758 |
2002 |
|
Acute monocytic leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML.
|
15936816 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
|
8806687 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
In APL cases with cryptic PML-RARalpha rearrangements, the characteristic microparticulate pattern of PML staining was detected with partial colocalization with PIC 1, indicative of disruption of the nuclear bodies; whereas in t(11; 17)-associated APL, PML and PIC 1 remained colocalized within discrete nuclear bodies, as observed in non-APL cases.
|
9389704 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of p21Cip1 or p27Kip1 in the promyelocytic leukemia cell line HL60 accelerates its lineage-specific differentiation.
|
10697493 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression.
|
24821727 |
2014 |
|
Adenoameloblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Only the P16 and P21 genes were methylated in the AOT samples.
|
19679296 |
2009 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
BEFREE |
The labeling for p21(WAF1/CIP1) and p27Kip1 was lower in MUCs (2.7% and 35.3%, respectively) than in well-differentiated adenocarcinomas (4.2% and 48.6%, respectively).
|
12047142 |
2002 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
BEFREE |
We determined whether alterations in the expression of p53, p16(INK4) and p21(WAF1/CIP1) influence the invasiveness of a subset of gastric adenocarcinomas co-expressing TGFalpha and EGFR.
|
15246559 |
2004 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The messages of two p53-regulated genes, p21(WAF1/CIP1) and 14-3-3final sigma, were consistently underexpressed in the adenocarcinomas, suggesting that the p53 pathway itself might be compromised in this cancer type.
|
11752463 |
2001 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our study demonstrated the overexpression of p21WAF1/CIP1 as an early event in the development of pancreatic intraepithelial neoplasia in the group of chronic pancreatitis and invasive adenocarcinoma as well.
|
14628083 |
2003 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
LHGDN |
The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1).
|
18562088 |
2008 |
|
Adenocarcinoma
|
0.070 |
AlteredExpression
|
group |
BEFREE |
CDKN1A histone acetylation and gene expression relationship in gastric adenocarcinomas.
|
26567008 |
2017 |
|
Adenocarcinoma
|
0.070 |
Biomarker
|
group |
BEFREE |
We demonstrate here that exposing A549 human alveolar type 2 adenocarcinoma cells to hyperoxia (95% O(2)) for 0.5-24 h time-dependently increases phospho-ERK, phospho-p53(Ser15), p53, and p21(CIP1) protein levels.
|
15212949 |
2004 |
|
Adenocarcinoma of colon
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line.
|
11064455 |
2000 |
|
Adenocarcinoma of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
Using p21(WAF1)-deficient cells derived from the HCT116 colon adenocarcinoma cell line, we now show that p21(WAF1) is indeed responsible for the antiproliferative effects of the type II IFN, IFN-gamma.
|
10638704 |
1999 |
|
Adenocarcinoma of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
To verify whether KYNA affects cell cycle regulators, the protein expression of cyclin-dependent kinase inhibitor p21 Waf1/Cip1 was investigated in colon adenocarcinoma HT-29 cells exposed to KYNA.
|
22814028 |
2012 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1).
|
18562088 |
2008 |