|
Bronchopulmonary Dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that increased CDKN1A expression may be involved in the pathogenesis of BPD through alveolarization and lung retardation.
|
30755044 |
2019 |
|
Hydatidiform Mole
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study was performed to investigate the expression patterns of c-erbB-2 and Bcl-2 oncoproteins, p53, p21<sup>WAF1/CIP1</sup> and p63 tumor suppressor proteins and Ki-67 cell proliferation marker in HM.
|
30558966 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Absence of p21(WAF1/CIP1/SDI1) protects against osteopenia and minimizes bone loss after ovariectomy in a mouse model.
|
30970032 |
2019 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fexinidazole Winthrop (hereafter referred to as fexinidazole) is a DNA synthesis inhibitor developed by the Drugs for Neglected Diseases initiative (DNDi), in collaboration with Sanofi, for the oral treatment of human African trypanosomiasis (HAT) [commonly known as 'sleeping sickness'] and Chagas' disease.
|
30635838 |
2019 |
|
Renal interstitial fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated expression of XIST led to an increase in miR-93-5p expression, thereby decreasing CDKN1A and suppressing renal interstitial fibrosis in DN.
|
31545928 |
2019 |
|
Medullary carcinoma of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic risk association of CDKN1A and RET gene SNPs with medullary thyroid carcinoma: Results from the largest MTC cohort and meta-analysis.
|
31408923 |
2019 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This finding suggests that the dysregulation between hsa-let-7a-5p/CDKN1A and hsa-miR-92b-3p/GSTM3 pairs is associated with platinum-based chemoresistance of metastatic cancer cells.
|
31127646 |
2019 |
|
Cognitive changes
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The expression of these proteins in the 2% ethanol group was completely reversed when compared to the 50% ethanol group. p21 <sup>WAF1/CIP1</sup> was involved in the cognitive change induced by ethanol.
|
31254559 |
2019 |
|
Tubulointerstitial fibrosis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulated expression of XIST led to an increase in miR-93-5p expression, thereby decreasing CDKN1A and suppressing renal interstitial fibrosis in DN.
|
31545928 |
2019 |
|
Ductal Carcinoma In Situ with Microinvasion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, simultaneous use of ZnO@Glu-TSC NPs (1/2 MIC) in combination with CIP (1/2 MIC) significantly reduced the expression of <i>norA</i>, <i>norB, norC</i>, and <i>tet38</i> by 5.4-, 3.8-, 2.1-, and 3.4-fold, respectively, compared to the CIP alone.
|
30855211 |
2019 |
|
Leukemia, Myelomonocytic, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcriptomic rationale for synthetic lethality-targeting ERCC1 and CDKN1A in chronic myelomonocytic leukaemia.
|
29797327 |
2018 |
|
Monoclonal Gammopathy of Undetermined Significance
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein expression of cyclin-dependent kinase inhibitor p21<sup>Cip1/Waf1</sup> was significantly higher in smoldering multiple myeloma (SMM) compared to monoclonal gammopathy of undetermined significance (MGUS) (p = .02) or symptomatic multiple myeloma (MM) (p = .005).
|
29616856 |
2018 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.
|
28774888 |
2018 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma.
|
29970899 |
2018 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our observations suggest that miR372 promotes liver cancer cell cycle progress by activating cyclin-dependent kinase 2 (CDK2)-cyclin E-P21/Cip1 complex through miR372-YB-1-β-catenin-LEF/TCF4-PKM2-erbB-2 axis.
|
29858084 |
2018 |
|
Uveal melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CAP (20 μM) induced Ca<sup>2+</sup> transients and increased whole-cell currents in both the UM cell line and PM whereas TRPM8 agonists, 100 μM menthol and 20 μM icilin, blunted such responses in the UM cells.
|
30483120 |
2018 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a mechanistic manner, we also showed that SNHG1 bound to the histone methyltransferase enhancer of the zeste homolog 2 (EZH2, which is regarded as the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is an extremely conserved protein complex regulating gene expression with the help of methylating lysine 27 on histone H3), specifying the histone alteration pattern on the target genes, including CDKN1A, and, as a result, altered the CCA cell biology.
|
29970899 |
2018 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our observations suggest that miR372 promotes liver cancer cell cycle progress by activating cyclin-dependent kinase 2 (CDK2)-cyclin E-P21/Cip1 complex through miR372-YB-1-β-catenin-LEF/TCF4-PKM2-erbB-2 axis.
|
29858084 |
2018 |
|
Smoldering myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein expression of cyclin-dependent kinase inhibitor p21<sup>Cip1/Waf1</sup> was significantly higher in smoldering multiple myeloma (SMM) compared to monoclonal gammopathy of undetermined significance (MGUS) (p = .02) or symptomatic multiple myeloma (MM) (p = .005).
|
29616856 |
2018 |
|
Autoimmune pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.
|
28774888 |
2018 |
|
Retroviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Transcription and translation of cyclin-dependent kinase inhibitor 1 (p21<sup>Cip1</sup>) and SAM domain and HD domain-containing protein 1 (SAMHD1) were analyzed by TaqMan PCR and Western blot experiments. siRNA experiment was applied to study the role of p53 downstream gene p21<sup>Cip1</sup> in the restriction of retrovirus infection.
|
28793904 |
2017 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to investigate the association of two polymorphisms (rs2844337 and rs11237200) in the P21 protein (cell division control protein 42/Rac)-activated kinase 1 gene with susceptibility to schizophrenia (SCZ) in Chinese Zhuang and Chinese Han populations.
|
28450949 |
2017 |
|
Benign neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
None of the malignant and benign breast tumors were found to be hypermethylated at p21^Waf1/Cip1 gene promoter.
|
28106536 |
2017 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we found that mutp53 proteins hyper-transactivate p53-target gene CDKN1A upon glutamine deprivation, thus triggering cell cycle arrest and promoting cell survival.
|
27721412 |
2017 |
|
Renal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kr-POK (ZBTB7c) is a kidney cancer-related POK transcription factor that not only represses transcription of CDKN1A but also increases expression of FASN.
|
28571744 |
2017 |