|
Stomach Neoplasms
|
0.520 |
AlteredExpression
|
group |
BEFREE |
However, an inverse correlation was detected between both H3K9 and H4K16 acetylation at the -402 CDKN1A region and mRNA levels in gastric tumors (r = -0.51, p = 0.02; r = -0.60, p < 0.01, respectively).
|
26567008 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate whether p21 (WAF-1/CIP1) should be considered a potential candidate for human bladder cancer gene therapy, we determined: (1) the basal level of p21 expression in bladder cancer cell lines, (2) the response of bladder cancer cells to increased p21 expression following p21 adenovirus infection, and (3) the mechanism of growth inhibition produced by p21 overexpression.
|
10688044 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effect of ADM on cell cycle progression and expression of cell cycle regulating proteins in bladder cancer cell lines with various p53 and p21(WAF1/CIP1) status.
|
11277327 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden.
|
24777035 |
2014 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In order to assess potential p21WAF1/CIP1 gene alterations in human bladder cancer, we have examined this gene and its encoded product in a well-characterized cohort of 27 primary bladder tumors.
|
9114433 |
1996 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that TP53/CDKN1A double-mutant bladder cancer cells have a unique dependence on Chk1 activity for the G2-M cell-cycle checkpoint in response to chemotherapy-induced DNA damage.
|
25349305 |
2015 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importin-11 overexpression can promote BCa cell invasiveness, probably associated with the deregulation of CDKN1A and THBS1 primarily through the activation of the proteoglycans in cancer pathway and the classical BCa pathway.
|
29602637 |
2018 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We used lentivirus-mediated short hairpin RNA to knock down p21/Waf-1 in two bladder cancer cell lines EJ and 5637.
|
27622605 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer.
|
26191193 |
2015 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although a potential tumor suppressor gene, WAF1/p21 is expressed in bladder cancer.
|
9472102 |
1998 |
|
Malignant neoplasm of urinary bladder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the differential protein expression of biomarkers FGFR3, PI3K (subunits PI3Kp110α, PI3KClassIII, PI3Kp85), AKT, p21Waf1/Cip1 and cyclins D1 and D3 in T1 bladder cancer versus healthy tissue and to study their potential role as early recurrence markers.
|
27726892 |
2017 |
|
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that TP53/CDKN1A double-mutant bladder cancer cells have a unique dependence on Chk1 activity for the G2-M cell-cycle checkpoint in response to chemotherapy-induced DNA damage.
|
25349305 |
2015 |
|
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the differential protein expression of biomarkers FGFR3, PI3K (subunits PI3Kp110α, PI3KClassIII, PI3Kp85), AKT, p21Waf1/Cip1 and cyclins D1 and D3 in T1 bladder cancer versus healthy tissue and to study their potential role as early recurrence markers.
|
27726892 |
2017 |
|
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effect of ADM on cell cycle progression and expression of cell cycle regulating proteins in bladder cancer cell lines with various p53 and p21(WAF1/CIP1) status.
|
11277327 |
2000 |
|
Bladder Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlation and prognostic significance of p53, p21WAF1/CIP1 and Ki-67 expression in patients with superficial bladder tumors treated with bacillus Calmette-Guerin intravesical therapy.
|
10022686 |
1999 |
|
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
We used lentivirus-mediated short hairpin RNA to knock down p21/Waf-1 in two bladder cancer cell lines EJ and 5637.
|
27622605 |
2017 |
|
Bladder Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Clinicopathologic and prognostic significance of p21 (Cip1/Waf1) expression in bladder cancer.
|
26191193 |
2015 |
|
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate whether p21 (WAF-1/CIP1) should be considered a potential candidate for human bladder cancer gene therapy, we determined: (1) the basal level of p21 expression in bladder cancer cell lines, (2) the response of bladder cancer cells to increased p21 expression following p21 adenovirus infection, and (3) the mechanism of growth inhibition produced by p21 overexpression.
|
10688044 |
2000 |
|
Bladder Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importin-11 overexpression can promote BCa cell invasiveness, probably associated with the deregulation of CDKN1A and THBS1 primarily through the activation of the proteoglycans in cancer pathway and the classical BCa pathway.
|
29602637 |
2018 |
|
Bladder Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although a potential tumor suppressor gene, WAF1/p21 is expressed in bladder cancer.
|
9472102 |
1998 |
|
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In order to assess potential p21WAF1/CIP1 gene alterations in human bladder cancer, we have examined this gene and its encoded product in a well-characterized cohort of 27 primary bladder tumors.
|
9114433 |
1996 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer.
|
24465590 |
2014 |
|
Malignant Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
High expression of waf-1 in nonmalignant long-standing UC has to be proved over a long-term course in its role as an independent cancer risk factor in UC patients.
|
11865380 |
2002 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Epigenetic Regulation of p21<sup>cip1/waf1</sup> in Human Cancer.
|
31514410 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Cellular levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), TP53, and p21<sup>waf1/cip1</sup> were measured in both cancer and surrounding tissues using an immunohistochemistry assay.
|
28903351 |
2017 |