Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The goal of this study is to test association between HOXB13 genetic variants and PCa risk in Chinese men.
|
22718278 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in HOXB13 and prostate-cancer risk.
|
22236224 |
2012 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey.
|
24722062 |
2014 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland.
|
23334858 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that risk alleles of HOXB13 and common variant SNPs are important components of inherited PCa risk in the Norwegian population, although these factors appear to contribute little to the malignancy's aggressiveness.
|
29181843 |
2018 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Our study confirmed the association between the G84E mutation of HOXB13 and risk of prostate cancer among subjects of European descent.
|
22714738 |
2012 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pedigree analysis of cases and controls revealed that 7/21 HOXB13 mutation carriers had a family history of prostate cancer.
|
23541221 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association with PCa risk was statistically significant for variants in BRCA2 (P < 0.001, OR = 5.65, 95% CI = 3.55-9.32), HOXB13 (P < 0.001, OR = 4.73, 95% CI = 2.84-8.19), and ATM (P < 0.001, OR = 2.86, 95% CI = 1.63-5.15).
|
31214711 |
2019 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The G84E variant of HOXB13 was recently found to be associated with a significantly increased risk of prostate cancer in a case control study.
|
23036981 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Updated insights into genetic contribution to prostate cancer predisposition: focus on HOXB13.
|
31629417 |
2019 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For example, a recent study suggested that one cannot adequately impute the HOXB13 G84E mutation associated with prostate cancer risk (carrier frequency of 0.0034 in European ancestry participants in the 1000 Genomes Project).
|
25629170 |
2015 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recently, a rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate cancer risk.
|
23064873 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Most notably, HOXB13 and BRCA2 mutations have been consistently shown to increase prostate cancer risk, and are more commonly observed among patients diagnosed with early-onset disease.
|
27899188 |
2016 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Collaborative investigations using next-generation sequencing to identify genetic variants associated with prostate cancer risk have revealed the significance of HOXB13, BRCA 1/2, and DNA repair mutations.
|
28442163 |
2017 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the G84E mutation of HOXB13, a relatively recent mutation that likely occurred in Northern Europe, significantly increases risk for PCa.
|
23393222 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This information can be used to assess more personalised prostate cancer risks to men who carry HOXB13 mutations and hence better counsel them on more personalised risk management options, such as tailoring prostate cancer screening frequency.
|
30527799 |
2019 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional genotyping, conditional regression and haplotype analyses indicated that the newly identified common variants tag a rare, partially correlated coding variant in the HOXB13 gene (rs138213197" genes_norm="10481">G84E, rs138213197), which has been identified recently as a moderate penetrance PrCa susceptibility allele.
|
24550738 |
2014 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 G84E was observed in 1.3% of population controls and was strongly associated with prostate cancer risk (CAPS: odds ratio [OR]: 3.4; 95% confidence interval [CI], 2.2-5.4; Stockholm-1: OR: 3.5; 95% CI, 2.4-5.2).
|
22841674 |
2014 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HOXB13 G84E mutation was identified in 0.49% of controls and in 2.51% of PCa cases.
|
26779768 |
2016 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.
|
26108461 |
2015 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data show that combined MYC activation and Pten loss driven by the Hoxb13 regulatory locus synergize to induce genomic instability and aggressive prostate cancer that phenocopies the human disease at the histologic and genomic levels.
|
26554830 |
2016 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe.
|
23104005 |
2012 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer.
|
23292082 |
2013 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
For example, a recent study suggested that one cannot adequately impute the HOXB13 G84E mutation associated with prostate cancer risk (carrier frequency of 0.0034 in European ancestry participants in the 1000 Genomes Project).
|
25629170 |
2015 |
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.
|
23396964 |
2013 |