HOXB13, homeobox B13, 10481

N. diseases: 90; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.500 CausalMutation disease CLINVAR
CUI: C1970250
Disease: Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 9 		0.400 CausalMutation disease CLINVAR
CUI: C1970250
Disease: Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 9 		0.400 Biomarker disease CTD_human
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 CausalMutation disease CLINVAR
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.110 CausalMutation disease CLINVAR
CUI: C3469524
Disease: PROSTATE CANCER, SUSCEPTIBILITY TO
PROSTATE CANCER, SUSCEPTIBILITY TO 		0.100 CausalMutation phenotype CLINVAR
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary 		0.100 GeneticVariation group CLINVAR Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. 8756292 1996
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.010 AlteredExpression group BEFREE Expression in hyperproliferative skin conditions remained cytoplasmic with the exception of epidermis associated with Kaposi's sarcoma, which showed strong HOXB13 expression that was partially localized to the nucleus. 12761847 2003
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 Biomarker disease BEFREE In addition to the loss of HOXB13 expression, maintaining AR may be an important step for prostate cancer cells to tolerate the suppressor function of HOXB13. 15604291 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.500 AlteredExpression disease BEFREE Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. 15193263 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. 15193263 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.380 AlteredExpression group LHGDN HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. 15126340 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.380 AlteredExpression group LHGDN HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. 15604291 2004
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.200 Biomarker disease BEFREE In addition to the loss of HOXB13 expression, maintaining AR may be an important step for prostate cancer cells to tolerate the suppressor function of HOXB13. 15604291 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE However, the function of HOXB13 in normal cell growth and tumorigenesis is not yet known. 15126340 2004
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 AlteredExpression phenotype BEFREE Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. 15193263 2004
CUI: C2986665
Disease: Early-Stage Breast Carcinoma
Early-Stage Breast Carcinoma 		0.030 AlteredExpression disease BEFREE The HOXB13:IL17BR expression ratio may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer. 15193263 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 AlteredExpression disease BEFREE Quantitative RT-PCR demonstrated the specificity of expression of HOXB13 in prostate tissue and revealed its ubiquitous expression in a series of 37 primary prostate cancers and 20 normal prostates. 15583692 2005
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.200 Biomarker disease BEFREE Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer. 15583692 2005
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary 		0.100 GeneticVariation group CLINVAR Hoxb13 up-regulates transglutaminase activity and drives terminal differentiation in an epidermal organotypic model. 15964834 2005
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 AlteredExpression phenotype BEFREE To study the role of HOXB13 in colorectal tumorigenesis, we evaluated the expression of HOXB13 in 53 colorectal tumours originated from the distal left colon to rectum with their matching normal tissues using quantitative RT-PCR analysis. 15928669 2005
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE This is the first description of the downregulation of HOXB13 in CRC and its mechanism of action is mediated through the regulation of TCF4 protein stability. 15928669 2005
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.030 AlteredExpression disease BEFREE HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. 15928669 2005
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.010 Biomarker group LHGDN Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer. 15756448 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.360 Biomarker group LHGDN The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. 17008703 2006