|
Adenoid Cystic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry of protein expressions validated 4 upregulated genes (ODAM, HOXB13, MYB and SOX10) considered important and as potential biomarkers for spiradenomas and cylindromas.
|
31128548 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, this study revealed the prognostic potential of HOXB13 in GBM.
|
31062400 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> High expression of HOXB13 observed in 17.8% of the lung adenocarcinoma patients in this study promoted cancer progression and predicted poor prognosis.
|
31037158 |
2019 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC-AS3.
|
31062400 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC-AS3.
|
31062400 |
2019 |
|
Eccrine spiradenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry of protein expressions validated 4 upregulated genes (ODAM, HOXB13, MYB and SOX10) considered important and as potential biomarkers for spiradenomas and cylindromas.
|
31128548 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, this study revealed the prognostic potential of HOXB13 in GBM.
|
31062400 |
2019 |
|
Refractory Cytopenia of Childhood
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tissue sample analysis showed that HOXB13 was differentially expressed between normal and only RCC tumor tissues.
|
31815008 |
2019 |
|
aggressive cancer
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We believed that HOXB13/HOXC-AS3 signaling axis can be served as therapeutic targets for this highly aggressive cancer.
|
31062400 |
2019 |
|
Glioma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, our study indicated that HOXB13-AS1 could regulate HOXB13 gene expression by methylation HOXB13 promoter and acts as an epigenetic oncogenic in glioma.
|
30105866 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased HOXB13 mRNA expression was due to DNA hypermethylation as following treatment with the DNA methyltransferase inhibitor 5-Aza-dC, HOXB13 expression in the GC MKN-45 cell line was upregulated.
|
29928325 |
2018 |
|
Familial lichen amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome.
|
29236593 |
2018 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased HOXB13 mRNA expression was due to DNA hypermethylation as following treatment with the DNA methyltransferase inhibitor 5-Aza-dC, HOXB13 expression in the GC MKN-45 cell line was upregulated.
|
29928325 |
2018 |
|
Metastatic castration-resistant prostate cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer.
|
30242092 |
2018 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that HOXB13 and HOXA9 were selectively expressed in spinal EPN instead of astrocytoma.
|
25785959 |
2017 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
HOXB13 a useful marker in pleomorphic giant cell adenocarcinoma of the prostate: a case report and review of the literature.
|
28484843 |
2017 |
|
Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 types of EPN and a promising therapeutic target for MEPN.
|
25785959 |
2017 |
|
Adult Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 types of EPN and a promising therapeutic target for MEPN.
|
25785959 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma.
|
27956498 |
2017 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in LSCC.
|
28808656 |
2017 |
|
Newly Diagnosed Childhood Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 types of EPN and a promising therapeutic target for MEPN.
|
25785959 |
2017 |
|
Childhood Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 types of EPN and a promising therapeutic target for MEPN.
|
25785959 |
2017 |
|
Childhood Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that HOXB13 and HOXA9 were selectively expressed in spinal EPN instead of astrocytoma.
|
25785959 |
2017 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HOXB13 was highly expressed in the ERα-negative subtype (r = -0.204, p = 0.002) and low expression of ESR1 was associated with a poor prognosis for EC patients (log-rank p < 0.05).
|
27018308 |
2016 |
|
Carcinoma, Transitional Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies suggested that HOXB13 represents a prostate-specific marker in the differential diagnosis between prostatic and urothelial carcinoma.
|
26590121 |
2016 |