HOXB13, homeobox B13, 10481

N. diseases: 90; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.500 CausalMutation disease CLINVAR
CUI: C1970250
Disease: Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 9 		0.400 CausalMutation disease CLINVAR
CUI: C1970250
Disease: Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 9 		0.400 Biomarker disease CTD_human
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 CausalMutation disease CLINVAR
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.110 CausalMutation disease CLINVAR
CUI: C3469524
Disease: PROSTATE CANCER, SUSCEPTIBILITY TO
PROSTATE CANCER, SUSCEPTIBILITY TO 		0.100 CausalMutation phenotype CLINVAR
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE <b>Results:</b> High expression of HOXB13 observed in 17.8% of the lung adenocarcinoma patients in this study promoted cancer progression and predicted poor prognosis. 31037158 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression phenotype BEFREE <b>Results:</b> High expression of HOXB13 observed in 17.8% of the lung adenocarcinoma patients in this study promoted cancer progression and predicted poor prognosis. 31037158 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.500 Biomarker disease BEFREE Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively. 21999244 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker disease BEFREE Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively. 21999244 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer. 31815008 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.030 AlteredExpression disease BEFREE HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. 15928669 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. 17308270 2007
CUI: C0278493
Disease: Breast cancer recurrent
Breast cancer recurrent 		0.010 AlteredExpression disease BEFREE HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. 17308270 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 Biomarker group BEFREE HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. 20454457 2010
CUI: C0010701
Disease: Phyllodes Tumor
Phyllodes Tumor 		0.010 AlteredExpression disease BEFREE HOXB13 protein overexpression was found to be correlated with stromal hypercellularity and atypia (P = 0.03, P = 0.039, respectively) and may be implicated in the development of malignant phyllodes tumors. 20945089 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 GeneticVariation disease BEFREE HOXB13 G84E was observed in 1.3% of population controls and was strongly associated with prostate cancer risk (CAPS: odds ratio [OR]: 3.4; 95% confidence interval [CI], 2.2-5.4; Stockholm-1: OR: 3.5; 95% CI, 2.4-5.2). 22841674 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.200 GeneticVariation disease BEFREE HOXB13 G84E was observed in 1.3% of population controls and was strongly associated with prostate cancer risk (CAPS: odds ratio [OR]: 3.4; 95% confidence interval [CI], 2.2-5.4; Stockholm-1: OR: 3.5; 95% CI, 2.4-5.2). 22841674 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation disease BEFREE HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. 23292082 2013
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.030 GeneticVariation disease BEFREE HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. 23292082 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 GeneticVariation disease BEFREE HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease. 23396964 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.200 GeneticVariation disease BEFREE HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease. 23396964 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.500 Biomarker disease BEFREE HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression. 23832664 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker disease BEFREE HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression. 23832664 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.600 Biomarker disease BEFREE HOXB13, RFX6 and prostate cancer risk. 24473320 2014