|
Acquired flat foot
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podoplanin was identified as a protein associated with the transformation of arborized foot processes of glomerular epithelial cells (podocytes) to flat feet.
|
25920588 |
2015 |
|
Acute intermittent porphyria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podoplanin (Th17 marker)-expressing lymphocytes were present in the lymphoid follicles of those with follicular pancreatitis, whereas these were absent in normal lymph nodes and in lymphoid follicles of those with IgG4-related autoimmune pancreatitis (AIP).
|
30515871 |
2019 |
|
Acute interstitial pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podoplanin (Th17 marker)-expressing lymphocytes were present in the lymphoid follicles of those with follicular pancreatitis, whereas these were absent in normal lymph nodes and in lymphoid follicles of those with IgG4-related autoimmune pancreatitis (AIP).
|
30515871 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction.
|
31287805 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PDPN-expressing primary APL cells, but not PDPN-negative primary leukemias, specifically induce platelet binding, activation and aggregation.
|
29550835 |
2018 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
LHGDN |
Podoplanin (+) CAFs were found only in invasive adenocarcinoma and none were found in noninvasive adenocarcinoma.
|
18546264 |
2008 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Stromal podoplanin expression was associated with poorer prognosis in adenocarcinoma (P < .001) and remains statistically significant after adjustment for sex, age, and stage (P = .01).
|
20923309 |
2010 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
Surgically resected human tumors revealed that the MIB-1 index of adenocarcinoma cells was significantly higher in the case of podoplanin (+) CAFs than in the case of podoplanin (-) CAFs (34.8% vs. 16.2%; p < 0.01).
|
31319967 |
2019 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
The number of podoplanin-positive cancer-associated fibroblasts and CD204-positive tumor-associated macrophages was significantly lower in Lep+ adenocarcinomas (podoplanin-positive cancer-associated fibroblasts: 0 vs 0 [mean: 1.6 vs 11.6], P < .01; CD204-positive tumor-associated macrophages: 8.7 vs 24.7, P < .01).
|
30257286 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma.
|
25648219 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Therefore, in this study, we immunohistochemically evaluated the expression of alpha-smooth muscle actin (α-SMA), podoplanin, and periostin among these proposed markers in 92 cases of lung adenocarcinoma.
|
31134329 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the EGFR-TKI sensitivity of EGFR-mutant lung adenocarcinoma cell lines cocultured with podoplanin-expressing CAFs.
|
25388165 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Podoplanin expression in cancer-associated fibroblasts (CAFs) has been proposed as an unfavourable indicator in squamous cell carcinoma of the lung, but little is known about its clinical significance in early-stage lung adenocarcinoma.
|
28881047 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, the analysis of small-sized human lung adenocarcinoma (n = 112) revealed that patients with podoplanin-positive cancer-associated fibroblasts had a significantly higher rate of lymph node metastasis and a high risk of recurrence.
|
21610106 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We compared the expression levels of immune-regulatory cytokines between the PDPN high and low expression groups by analyzing the gene expression profiles of lung adenocarcinoma (n = 442).
|
30527194 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the presence of abundant tumor promoting stromal cells, CD204 (+) TAMs, and podoplanin (+) CAFs is characteristic of the tumor microenvironment containing CAIX (+) CAFs, which contributes to an increase in aggressive behavior in lung adenocarcinoma with hypoxic regions.
|
29290263 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.
|
29511884 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.090 |
Biomarker
|
disease |
BEFREE |
Podoplanin and fibroblast growth factor (FGF) 1 have been detected more frequently in lung squamous cell carcinoma (SQCC) compared with lung adenocarcinoma.
|
28656229 |
2017 |
|
Adenoid cystic carcinoma of salivary gland
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, podoplanin is overexpressed in a subset of SACCs and may be a biomarker predicting distant metastasis in patients with SACC.
|
22580922 |
2012 |
|
Adenomatoid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The tumor cells of ATs commonly expressed calretinin and podoplanin.
|
30099776 |
2018 |
|
Adult Alveolar Soft Part Sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical and quantitative real-time RT-PCR analyses demonstrated the expression of the podoplanin protein and mRNA in the majority of benign and malignant soft tissue tumors and tumor-like lesions examined, with the exception of alveolar soft part sarcoma, embryonal and alveolar rhabdomyosarcoma, extraskeletal Ewing's sarcoma/peripheral primitive neuro-ectodermal tumor and lipoma, which were completely negative for podoplanin.
|
21234520 |
2011 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In 11 of 43 anaplastic astrocytomas (25.6%) and in 54 of 115 glioblastomas (47.0%), podoplanin was expressed on the surface of anaplastic astrocytoma cells and glioblastoma cells, especially around necrotic areas and proliferating endothelial cells.
|
16596424 |
2006 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The increase and/or maintenance of high podoplanin expression in serial transplantations and in podoplaninlow-sorted glioblastoma cells during outgrowth indicated the association of high podoplanin expression and poor outcome.
|
30418623 |
2019 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma.
|
20665731 |
2010 |
|
Albuminuria
|
0.200 |
Biomarker
|
phenotype |
RGD |
Albuminuria developed starting at 6 wk of age and coincided with focal and segmental loss of podoplanin, increased expression of desmin, entrapment of albumin in affected podocytes, and focal and segmental foot process effacement at the ultrastructural level.
|
18199599 |
2008 |