PDPN, podoplanin, 10630

N. diseases: 256; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0375021
Disease: Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site
Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site 		0.030 Biomarker disease BEFREE Using a specific monoclonal antibody, we showed here that gp80 is a dimeric form of the transmembrane glycoprotein gp36 of HIV-2. 2296088 1990
CUI: C0341038
Disease: Jaw Keratocyst
Jaw Keratocyst 		0.030 Biomarker disease BEFREE We have identified strong expression of a 38-kD cell surface glycoprotein (gp38), a marker of basal cell carcinomas (BCCs), in basal and suprabasal epithelial cell membranes of parakeratinised odontogenic keratocysts. 7506776 1993
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.020 Biomarker disease BEFREE We have identified strong expression of a 38-kD cell surface glycoprotein (gp38), a marker of basal cell carcinomas (BCCs), in basal and suprabasal epithelial cell membranes of parakeratinised odontogenic keratocysts. 7506776 1993
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.010 AlteredExpression disease BEFREE The glycoprotein gp38 is overexpressed in 90% of ovarian carcinomas and recognized by monoclonal antibodies MOv18 and MOv19. 8242637 1993
CUI: C0004626
Disease: Pneumonia, Bacterial
Pneumonia, Bacterial 		0.200 Biomarker group RGD A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia. 7864138 1995
CUI: C0027720
Disease: Nephrosis
Nephrosis 		0.200 Biomarker disease RGD Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. 9327748 1997
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Podoplanin expression in primary KS tumor lysates was confirmed by Western blot analysis. 10068212 1999
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.020 AlteredExpression disease BEFREE In contrast to KS tumor cells in situ, no expression of VEGFR-3 and podoplanin was detected in any of four KS-derived spindle cell cultures and in one KS-derived autonomously growing cell line (KS Y-1). 10068212 1999
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE In this study we have shown that gp40, a mucin-like glycoprotein, is localized to the surface and apical region of invasive stages of the parasite and is shed from its surface. gp40-specific antibodies neutralize infection in vitro, and native gp40 binds specifically to host cells, implicating this glycoprotein in C. parvum attachment to and invasion of host cells. 10858228 2000
CUI: C0010418
Disease: Cryptosporidiosis
Cryptosporidiosis 		0.010 Biomarker disease BEFREE The surface localization of gp40 and gp15 and their involvement in the host-parasite interaction suggest that either or both of these glycoproteins may serve as effective targets for specific preventive or therapeutic measures for cryptosporidiosis. 10858228 2000
CUI: C0375021
Disease: Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site
Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site 		0.030 Biomarker disease BEFREE This ELISA, using a specific immunodominant epitope (11 amino acids) from the transmembrane (gp36) portion of the HIV-2 envelope glycoprotein showed a high concordance with PCR findings. 11418351 2001
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.210 Biomarker disease RGD Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. 11790662 2002
CUI: C0079924
Disease: Oligohydramnios
Oligohydramnios 		0.200 Biomarker phenotype RGD Effects of oligohydramnios on lung growth and maturation in the fetal rat. 11839536 2002
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE This gene encodes a precursor protein that is proteolytically cleaved to yield mature cell surface glycoproteins gp40 and gp15, which are implicated in zoite attachment to and invasion of enterocytes. 12065532 2002
CUI: C0242706
Disease: Hyperoxia
Hyperoxia 		0.200 Biomarker phenotype RGD Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase. 12922978 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE Podoplanin expression was also increased in the cancer samples. 12851706 2003
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE Podoplanin expression was also increased in the cancer samples. 12851706 2003
CUI: C0018916
Disease: Hemangioma
Hemangioma 		0.020 Biomarker disease BEFREE By contrast, blood vessel endothelium and hemangiomas were strongly positive for PAL-E and CD34 but were mostly negative for CD9 and podoplanin. 14559986 2003
CUI: C0027668
Disease: Neoplasms, Vascular Tissue
Neoplasms, Vascular Tissue 		0.020 AlteredExpression group BEFREE Using immunohistochemistry, expression of CD9 was studied in 17 samples of head and neck mucosa and skin (laryngeal mucosa: n = 2, oral: n = 6, and epidermis: n = 9) and a variety of vascular tumors (lymphangiomas: n = 9, juvenile nasopharyngeal angiofibromas: n = 4, hemangiomas: n = 7, angiosarcomas: n = 5, and Kaposi's sarcomas: n = 7) and compared with the expression of CD34 and PAL-E (blood vessel markers) and the lymphatic marker podoplanin. 14559986 2003
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.020 AlteredExpression disease BEFREE Using immunohistochemistry, expression of CD9 was studied in 17 samples of head and neck mucosa and skin (laryngeal mucosa: n = 2, oral: n = 6, and epidermis: n = 9) and a variety of vascular tumors (lymphangiomas: n = 9, juvenile nasopharyngeal angiofibromas: n = 4, hemangiomas: n = 7, angiosarcomas: n = 5, and Kaposi's sarcomas: n = 7) and compared with the expression of CD34 and PAL-E (blood vessel markers) and the lymphatic marker podoplanin. 14559986 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 AlteredExpression group LHGDN Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. 14522983 2003
CUI: C0024221
Disease: Lymphangioma
Lymphangioma 		0.010 Biomarker disease BEFREE Regular lymphatic endothelium and lymphangiomas were strongly positive for CD9 and podoplanin but were mostly negative for PAL-E and CD34. 14559986 2003
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.010 Biomarker disease BEFREE The arrays permitted the simultaneous serodetection of antibodies directed against hepatitis C virus (HCV core p21 15-45 peptide, NS4 1925-1947 peptide, core, NS3, NS4, and mixture of core, NS3, NS4, and NS5 antigens), hepatitis B virus (HBc, HBe, and HBs), human immunodeficiency virus (Gp41 and Gp120 for HIV-I and Gp36 for HIV-II), Epstein-Barr virus (VCAp18 153-176 peptide), and syphilis (rTpN47 and rTpN17) antigens using an immunofluorescence assay. 15025526 2004
CUI: C0039128
Disease: Syphilis
Syphilis 		0.010 Biomarker disease BEFREE The arrays permitted the simultaneous serodetection of antibodies directed against hepatitis C virus (HCV core p21 15-45 peptide, NS4 1925-1947 peptide, core, NS3, NS4, and mixture of core, NS3, NS4, and NS5 antigens), hepatitis B virus (HBc, HBe, and HBs), human immunodeficiency virus (Gp41 and Gp120 for HIV-I and Gp36 for HIV-II), Epstein-Barr virus (VCAp18 153-176 peptide), and syphilis (rTpN47 and rTpN17) antigens using an immunofluorescence assay. 15025526 2004
CUI: C0021368
Disease: Inflammation
Inflammation 		0.200 Biomarker phenotype RGD Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types. 15849211 2005