|
Congenital small ears
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Strong reduction of WIF1 protein expression was found in 23% of prostate carcinomas, but also in 60% of breast, 75% of non-small cell lung (NSCLC), and 26% of bladder cancers analysed.
|
14517837 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No significant association between WIF1 down-regulation and tumour stage or grade was observed for prostate, breast or non-small cell lung carcinomas, indicating that loss of WIF1 expression may be an early event in tumourigenesis in these tissues.
|
14517837 |
2003 |
|
Bladder Neoplasm
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.
|
14517837 |
2003 |
|
Malignant neoplasm of urinary bladder
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Strong reduction of WIF1 protein expression was found in 23% of prostate carcinomas, but also in 60% of breast, 75% of non-small cell lung (NSCLC), and 26% of bladder cancers analysed.
|
14517837 |
2003 |
|
Carcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Strong reduction of WIF1 protein expression was found in 23% of prostate carcinomas, but also in 60% of breast, 75% of non-small cell lung (NSCLC), and 26% of bladder cancers analysed.
|
14517837 |
2003 |
|
Carcinoma of bladder
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.
|
14517837 |
2003 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
WIF1 was down-regulated in 64% of primary prostate cancers, while SFRP4 was up-regulated in 81% of the patients.
|
14517837 |
2003 |
|
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed.
|
15019166 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines.
|
15019166 |
2004 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells.
|
15019166 |
2004 |
|
Malignant neoplasm of colon and/or rectum
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed.
|
15019166 |
2004 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines.
|
15019166 |
2004 |
|
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We then studied WIF-1 expression in 18 freshly resected lung cancers, and we show a down-regulation in 15 of them (83%).
|
15256437 |
2004 |
|
Carcinoma of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To discover the mechanism of WIF-1 silencing in lung cancer, we first identified the human WIF-1 promoter and subsequently examined the methylation status in the CpG islands.
|
15256437 |
2004 |
|
Primary malignant neoplasm of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To discover the mechanism of WIF-1 silencing in lung cancer, we first identified the human WIF-1 promoter and subsequently examined the methylation status in the CpG islands.
|
15256437 |
2004 |
|
Prostatic Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.
|
15389810 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
LHGDN |
Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.
|
15735743 |
2005 |
|
Colorectal Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
It has been reported that WIF-1 expression is down regulated in several solid tumors and that WIF-1 is silenced by promoter hypermethylation in lung and colorectal cancer.
|
16007117 |
2005 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Downregulation of WIF-1 mRNA expression was observed in 61 (91.0%) of 67 cancer cell lines, 16 (80.0%) of 20 esophageal, 23 (74.2%) of 31 gastric, 41 (82.0%) of 50 colorectal, and six (75.0%) of eight pancreatic cancer tissues.
|
16007117 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest tumor suppressive function of WIF-1, due to its ability to inhibit Wnt signaling.
|
16007117 |
2005 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
No significant association between WIF-1 downregulation and clinicopathological characteristics was found, suggesting that downregulation of WIF-1 expression is an early event in carcinogenesis of these cancers.
|
16007117 |
2005 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Downregulation of WIF-1 mRNA expression was observed in 61 (91.0%) of 67 cancer cell lines, 16 (80.0%) of 20 esophageal, 23 (74.2%) of 31 gastric, 41 (82.0%) of 50 colorectal, and six (75.0%) of eight pancreatic cancer tissues.
|
16007117 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
0.070 |
PosttranslationalModification
|
disease |
BEFREE |
It has been reported that WIF-1 expression is down regulated in several solid tumors and that WIF-1 is silenced by promoter hypermethylation in lung and colorectal cancer.
|
16007117 |
2005 |
|
Malignant tumor of colon
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Transfection of the WIF-1 gene construct into TE-1 esophageal cancer cell lines or SW48 colon cancer cell lines lacking WIF-1 expression resulted in a significant inhibition on colony formation, cell proliferation, anchorage-independent growth in soft agar.
|
16007117 |
2005 |