|
Actinic cheilitis
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
According to our current findings, Wif1 promoter methylation is an early, frequent event as an epigenetic field manner and could be considered as a useful prognostic marker for AC patients with EGFR mutation.
|
23686431 |
2013 |
|
Actinic cheilitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Either intracellular β-catenin accumulation or β-catenin mRNA transcription was significantly elevated in the AC tumors, which also showed an inverse correlation with Wif-1 mRNA transcription.
|
24755523 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, Wnt inhibitory factor-1 methylation was found in APL (4 of 6 patients) but not in CBF leukaemia (0 of 12 patients) (P = 0.001).
|
17686056 |
2007 |
|
Adenocarcinoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of EZH2 and β-catenin with concomitant decrease in WIF1 expression in the polyps of CR-infected Apc(Min/+) mice paralleled changes recorded in BLT1(-/-)Apc(Min/+), AOM/DSS and human adenocarcinomas.
|
25486432 |
2015 |
|
Adenocarcinoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In contrast, no significant difference in mean survival was observed in patients with lung squamous cell carcinoma and adenocarcinoma with positive and negative WIF-1 protein expression (P>0.05).
|
27801732 |
2018 |
|
Adenocarcinoma
|
0.050 |
Biomarker
|
group |
BEFREE |
In the present study, we conducted an immunohistochemical evaluation of PLAG1 and a reverse transcription-polymerase chain reaction (RT-PCR) assay to detect fusion gene transcripts associated with pleomorphic adenoma, including the CTNNB1-PLAG1, LIFR-PLAG1, CHCHD7-PLAG1, TCEA1-PLAG1, HMGA2-FHIT, HMGA2-NFIB, and HMGA2-WIF1 fusion transcripts; this was performed using formalin-fixed paraffin-embedded tumor tissue specimens of 16 cutaneous mixed tumors including one sample with an adenocarcinoma component.
|
21927843 |
2011 |
|
Adenocarcinoma
|
0.050 |
PosttranslationalModification
|
group |
BEFREE |
However, Wif1 methylation showed an association with unfavorable prognosis of adenocarcinoma (AC) patients with EGFR mutation.
|
23686431 |
2013 |
|
Adenocarcinoma
|
0.050 |
PosttranslationalModification
|
group |
BEFREE |
A distinct profile was apparent for the 2 groups of lung tumors and the frequencies of promoter hypermethylation at sFRP1 and WIF-1, 2 genes involved in Wnt signaling, and at CDH1 were significantly higher in colorectal metastases than in lung primaries, whereas methylation of the APC promoter was significantly more common in lung primary adenocarcinomas.
|
16991125 |
2006 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines.
|
15019166 |
2004 |
|
Adenoma
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
The hypermethylation of WIF-1 was detected in 60.4% (29/48), 45.7% (16/35) and 18.7% (6/32) of fecal samples from CRC, adenoma and hyperplastic polyp patients, respectively.
|
24876755 |
2014 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
We discovered widespread hypermethylation of the Wnt antagonists SFRP1, SFRP2, SFRP5, DKK2, WIF1 and SOX17 in the transition from normal to adenoma with only the Wnt antagonists SFRP1, SFRP2, DKK2 and WIF1 showing further significant increase in methylation from adenoma to carcinoma.
|
25432628 |
2014 |
|
Adenoma
|
0.040 |
Biomarker
|
group |
BEFREE |
BRBs significantly decreased cellular proliferation, DNA methylation methyl transferase 1 protein expression, and p16 promoter methylation, but not promoter methylation of the Wnt pathway antagonists, SFRP2 and WIF1, in rectal polyps (adenomas) from responders but not from nonresponders.
|
24764585 |
2014 |
|
Adenoma
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
WIF-1 and DKK3 showed a significantly lower level of methylation in nonpolypoid compared to polypoid adenomas (p < 0.01).
|
24350795 |
2013 |
|
Adenomatous Polyposis Coli
|
0.040 |
Biomarker
|
disease |
BEFREE |
We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.
|
29391809 |
2018 |
|
Adenomatous Polyposis Coli
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Alterations of Wnt signaling appear to be involved in the pathogenesis of osteosarcoma, presenting mutations of adenomatous polyposis coli (APC) and epigenetic downregulation of Wnt inhibitory factor 1.
|
22550000 |
2012 |
|
Adenomatous Polyposis Coli
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The activation of the Wnt/β-catenin signaling pathway in NSCLC could be initiated by WIF-1 gene inhibition without APC expression changes, and this may be different to the mechanism in other tumors.
|
28454231 |
2017 |
|
Adenomatous Polyposis Coli
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
After transfection with miR-BART19-3p mimics, the expression of WIF1, and APC decreased, and the cellular proliferation rate increased.
|
28543390 |
2017 |
|
Adult Glioblastoma
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Levels of WIF1 promoter methylation, mRNA expression, and protein expression in a glioblastoma cell line were compared before and after demethylation treatment.
|
23328978 |
2013 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, WIF1 overexpression in glioblastoma cells induced a senescence-like phenotype that was dose dependent.
|
21642372 |
2011 |
|
Adult Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Wnt inhibitory factor-1 regulates glioblastoma cell cycle and proliferation.
|
22901505 |
2012 |
|
Adult Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The WNT inhibitory factor 1 (WIF1), a secreted inhibitor of WNTs, is systematically downregulated in glioblastoma and acts as strong tumor suppressor.
|
25772239 |
2016 |
|
Advanced breast cancer
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Value of the level of methylation of RASSF1A and WIF-1 in tissue and serum in neoadjuvant chemotherapeutic assessment for advanced breast cancer.
|
28943958 |
2017 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
WIF1 and MET are implicated in Wnt and MET signaling and regulate GSK3β activity and are thus linked with AD.
|
29426890 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the correlation between HOTAIR and Wnt inhibitory factor 1 (WIF-1) expression in PDAC cell lines and tissues was studied to assess the role of HOTAIR and WIF-1 in the radiosensitivity of PDAC.
|
26482614 |
2016 |
|
Anorectal Malformations
|
0.020 |
Biomarker
|
group |
BEFREE |
Dysregulation of this endodermal Shh-Wif1-β-catenin signaling axis contributes to ARM pathogenesis.
|
24632949 |
2014 |