|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
No differences were observed in WIF-1 expression linked to a particular condition, but WIF-1 stain was significantly enhanced in the crypts and lamina propria as inflammation increased in biopsies from patients with both, ulcerative colitis and Crohn's disease.
|
30051904 |
2019 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
No differences were observed in WIF-1 expression linked to a particular condition, but WIF-1 stain was significantly enhanced in the crypts and lamina propria as inflammation increased in biopsies from patients with both, ulcerative colitis and Crohn's disease.
|
30051904 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings could give guidance to new therapeutic applications of the WNT/β-catenin system and WIF-1 in IBD.
|
30051904 |
2019 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gossypol Promotes Wnt/<i>β</i>-Catenin Signaling through WIF1 in Ovariectomy-Induced Osteoporosis.
|
31139657 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found new characteristic of thyroid tumours: methylation of TP73, WIF1 and PDLIM4 TSGs, which can contribute to thyroid neoplasia.
|
31006665 |
2019 |
|
Growth Hormone-Secreting Pituitary Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The H‑scores of SLC20A1 were negatively associated with those of Wif1 in somatotroph adenomas (correlation coefficient r=‑0.367).
|
31432167 |
2019 |
|
Congenital Dysplasia Of The Hip
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
WIF1 expression was compared among different genotypes in DDH patients.
|
30670715 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
WIF1 and MET are implicated in Wnt and MET signaling and regulate GSK3β activity and are thus linked with AD.
|
29426890 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Circulating Wnt inhibitory factor 1 levels are associated with development of cardiovascular disease.
|
29649633 |
2018 |
|
Disorder of eye
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, we highlight the potential of Wif1 research to understand and possibly influence mechanisms underlying eye diseases and regeneration.
|
30574494 |
2018 |
|
Pituitary Adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of TGF-β1 and WIF1 Expression with 36 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas: A High-Throughput Tissue Microarrays Immunohistochemical Study.
|
29966778 |
2018 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, no significant difference in mean survival was observed in patients with lung squamous cell carcinoma and adenocarcinoma with positive and negative WIF-1 protein expression (P>0.05).
|
27801732 |
2018 |
|
Non-Functioning Pituitary Gland Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of TGF-β1 and WIF1 in NFPAs correlated with cell proliferation and recurrence potential.
|
29966778 |
2018 |
|
Recurrent tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study was undertaken primarily to research transforming growth factor β1 (TGF-β1) and Wnt inhibitory factor 1 (WIF1) for the prediction of nonfunctioning pituitary adenoma (NFPAs) invasion and recurrence of tumor samples and the relations between quantitatively determined markers and clinical characters.
|
29966778 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The percentage of positive WIF-1 protein expression was significantly higher, while positive Ihh protein expression was significantly lower in patients with well-differentiated lung squamous cell carcinoma and adenocarcinoma, tumor node metastasis (TNM) stage I disease, and lymph node metastasis than that in patients with poorly differentiated tumor, TNM stage III disease, and lymph node metastasis (P<0.05, <0.01).
|
27801732 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrate by both ex vivo and xenograft experiments that inhibiting miR-221/222 expression in a TNBC cell line (MDA-MB-231) suppresses its proliferation, viability, epithelial-to-mesenchymal transition, and migration; whereas expressing miR-221/222 in a non-TNBC line (MCF7) promotes all of the above cancer properties. miR-221/222 achieve so by directly repressing multiple negative regulators of the Wnt/β-catenin signaling pathway, including WIF1, SFRP2, DKK2, and AXIN2, to activate the pathway.
|
30053090 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrate by both ex vivo and xenograft experiments that inhibiting miR-221/222 expression in a TNBC cell line (MDA-MB-231) suppresses its proliferation, viability, epithelial-to-mesenchymal transition, and migration; whereas expressing miR-221/222 in a non-TNBC line (MCF7) promotes all of the above cancer properties. miR-221/222 achieve so by directly repressing multiple negative regulators of the Wnt/β-catenin signaling pathway, including WIF1, SFRP2, DKK2, and AXIN2, to activate the pathway.
|
30053090 |
2018 |
|
Cholecystitis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
WIF-1 promoter methylation was present in 36 of 50 (72.0%) gallbladder cancers but only 5 of 20 (25.0%) cholecystitis tissues (P=0.000<0.05), suggesting that WIF-1 promoter methylation might participate in the malignant transformation of cholecystitis into gallbladder cancer.
|
28438695 |
2017 |
|
Chondrosarcoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, we found that WIF1 is epigenetically silenced via promoter DNA methylation in CS and propose that WIF1 methylation may serve as a potential prognostic marker for patients with CS.
|
28484252 |
2017 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to study the effects of Wnt/β-catenin pathway antagonists-secreted frizzled-related protein 1 and Wnt inhibitory factor 1-on resistance toward tyrosine kinase inhibitors in chronic myeloid leukemia.
|
28468589 |
2017 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to wild-type (WT) littermates, WIF1 knockout mice showed severe adverse remodeling marked by increased scar size and reduced ejection fraction 4 weeks after MI While FACS analysis on day 1 after MI revealed no differences in neutrophil numbers, the hearts of WIF1 knockouts contained significantly more inflammatory monocytes than hearts from WT animals.
|
28774883 |
2017 |
|
Osteopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Plausibly, homeostatic feedback loops that rely on Runx2 activation to compensate for bone loss in GIO are thwarted, exacerbating disease progression through stimulation of Wif1..
|
27061521 |
2017 |
|
Atrial Premature Complexes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After transfection with miR-BART19-3p mimics, the expression of WIF1, and APC decreased, and the cellular proliferation rate increased.
|
28543390 |
2017 |
|
Niemann-Pick Disease, Type C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to detect the effect of EBV on Wnt inhibitory factor 1 (WIF1), Nemo-like kinase (NLK), and adenomatous polyposis coli (APC) gene methylation, and expression in gastric carcinoma and NPC.
|
28543390 |
2017 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results indicate that WIF1 and ROR2 are important biomarkers in pancreatic cancer.
|
28454387 |
2017 |