WIF1, WNT inhibitory factor 1, 11197

N. diseases: 171; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152423
Disease: Congenital small ears
Congenital small ears 		0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 AlteredExpression disease BEFREE WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. 14517837 2003
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.040 AlteredExpression disease BEFREE WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. 14517837 2003
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 AlteredExpression disease BEFREE WIF1 was down-regulated in 64% of primary prostate cancers, while SFRP4 was up-regulated in 81% of the patients. 14517837 2003
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. 15019166 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Wif-1, a putative tumor suppressor, is a soluble negative regulator of the Wnt pathway activated in CLL. 16427695 2006
CUI: C0812413
Disease: Malignant Pleural Mesothelioma
Malignant Pleural Mesothelioma 		0.010 PosttranslationalModification disease BEFREE Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. 16516163 2006
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE WIF1 is an antagonist of the Wnt signaling pathway, which plays a critical role in human cancer. 17171686 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE WIF1 is an antagonist of the Wnt signaling pathway, which plays a critical role in human cancer. 17171686 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.070 AlteredExpression disease BEFREE Wif1 was highly expressed in the developing and mature mouse skeleton, and, although it was dispensable for normal development, targeted deletion of mouse Wif1 accelerated development of radiation-induced osteosarcomas in vivo. 19307728 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 PosttranslationalModification disease BEFREE WIF1 and DKK3 promoter methylation were detected in 63.3% (95/150) and 61.3% (92/150) of breast carcinoma samples, respectively. 19570204 2009
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE WIF-1 has been described as a tumor suppressor in various types of cancer. 19887605 2009
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE WIF-1 has been described as a tumor suppressor in various types of cancer. 19887605 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE WIF-1 transfection significantly induced apoptosis and suppressed in vivo tumor growth. 19887605 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 PosttranslationalModification disease BEFREE WIF-1 silencing as a result of its promoter hypermethylation may be a frequent event in HCC. 20119713 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. 20197388 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.060 Biomarker phenotype BEFREE Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. 20197388 2010
CUI: C0153676
Disease: Secondary malignant neoplasm of lung
Secondary malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE WIF-1 overexpression also markedly reduced the number of lung metastasis in vivo in an orthotopic mouse model of osteosarcoma. 20197388 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE WIF-1 is a negative regulator of the Wnt-signaling pathway that may have important implications for tumorigenesis. 20596629 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE WIF1 encodes a secreted Wnt antagonist and was strongly downregulated in most glioblastomas as compared with normal brain, implying deregulation of Wnt signaling, which is associated with cancer. 21642372 2011
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE WIF1 encodes a secreted Wnt antagonist and was strongly downregulated in most glioblastomas as compared with normal brain, implying deregulation of Wnt signaling, which is associated with cancer. 21642372 2011
CUI: C0279671
Disease: Cervical Squamous Cell Carcinoma
Cervical Squamous Cell Carcinoma 		0.010 PosttranslationalModification disease BEFREE WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. 21873353 2011
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.020 Biomarker disease BEFREE Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. 22002305 2012
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.020 Biomarker disease BEFREE Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. 22002305 2012
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.020 Biomarker disease BEFREE Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo. 22002305 2012