|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This study examined the association of COMT with salivary cortisol across a 1-year period in healthy and at-risk adolescents with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision Axis II diagnoses.
|
20421850 |
2010 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables).
|
28608575 |
2018 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The Catechol-O-methyltransferase (COMT) gene has been an important candidate risk factor for several psychiatric disorders.
|
28235603 |
2017 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The identification of candidate genes for heart anomalies, mental illness, and other clinical phenotypes has been reported in the past year with a focus on TBX1 for cardiac and craniofacial phenotypes and COMT and PRODH for psychiatric disorders.
|
16282778 |
2005 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The relationship between proline and COMT also appears to modify negative symptoms across psychiatric illness.
|
27622935 |
2016 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Future longitudinal studies focusing on additional COMT polymorphic sites and other candidate genes from the deleted region will elucidate the molecular pathways leading to schizophrenia and other psychiatric disorders in VCFS.
|
16734939 |
2007 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders.
|
20004480 |
2010 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Multivariate logistic regression model analysis showed that suicide impulsion and psychiatric disorders were significantly associated with COMT Val/Val, their OR values were 0.052 (95% CI: 0.006 - 0.437), 2.917 (95% CI: 1.097 - 7.760).
|
16780746 |
2006 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders.
|
15124004 |
2004 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The COMT gene is located on chromosome 22q11, a region strongly implicated in the aetiology of several psychiatric disorders, in particular schizophrenia.
|
16483362 |
2006 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome.
|
9707588 |
1998 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The gene encoding Catechol O-methyltransferase (COMT), a dopamine catabolic enzyme, is an important candidate gene in several psychiatric disorders.
|
20605701 |
2010 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system.
|
27548835 |
2016 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We then examined genetic polymorphisms in four candidate genes (DRD4, DAT, COMT and MAOA) that have been shown to contribute to the risk of developing various psychiatric disorders where attention is disrupted.
|
12366871 |
2002 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The COMT gene has been implicated to be involved in the pathogenesis of obsessive-compulsive disorder (OCD) and various other psychiatric disorders.
|
12900951 |
2003 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol O-methyltransferase (COMT) has been associated with aggression, attention deficit/hyperactivity disorder (ADHD), and other psychiatric disorders.
|
22972758 |
2013 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et al., 1997; Vandenbergh et al., 1997; Papolos et al., 1998; Tiihonen et al., 1999).
|
11204347 |
2000 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism.
|
10395222 |
1999 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In particular, the impulsive-hyperactive type of ADHD (excluding inattention) ascertained by Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria (chi(2) = 8.34, p = 0.004, df = 1), by the Conners Teaching Rating Hyperactivity scale (Pearson chi(2) = 5.32, p = 0.02, df = 1) as well as by the Continuous Performance Test False Alarm scale (chi(2) = 2.78, p = 0.096, df = 1) were associated with the high enzyme activity COMT val allele.
|
10490706 |
1999 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.
|
21465565 |
2011 |