|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Stratification analysis found a significantly increased risk for RA associated with the APOM rs805297 TT genotype among male patients, C-reactive protein (CRP)-positive patients, anticitrullinated protein/peptide antibodies (ACPA) - positive patients, rheumatoid factor (RF) - positive patients, patients with higher levels of the erythrocyte sedimentation rate (ESR), patients with higher DAS28 score and patients with higher functional class compared to the APOM rs805297 GG genotype.
|
23660425 |
2014 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We further investigated the relationships among the genotypes of each polymorphism and C-reactive protein or rheumatoid factor levels in RA patients.
|
15565336 |
2005 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), disease activity score (DAS), visual analog scala (VAS), HLA genotype and radiographic information were determined in patients with RA.
|
18418600 |
2008 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we evaluated the frequency and potential impact of IL-10 promoter polymorphisms on susceptibility to and severity of RA in Polish in - patients with a high disease activity (mean DAS 28 C-reactive protein 5.25).
|
20477882 |
2010 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
|
27534721 |
2016 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.
|
30729371 |
2019 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genotype FGB -455G>A (rs1800790) was associated with CRP elevations (≥ 10 mg/l) in both cohorts (RA, OR per allele 0.69, p=0.0007/P(adj)<0.015; non-RA, OR 0.70, p=0.0004/p(adj)<0.02; combined, OR 0.69, p<10(-5)/p(adj)=0.001).
|
22267327 |
2012 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the MSRA rs10903323 G/A variant allele is associated with RA development, especially among male patients, older patients, CRP-positive patients, and anti-CCP negative patients.
|
23244167 |
2013 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with RA who had the LTA 252 G/G genotype were younger at disease onset and had higher C-reactive protein (CRP) levels.
|
21459939 |
2011 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of IRAK1 single-nucleotide polymorphism (SNP) rs3027898 (IRAK1 rs3027898) and miR-146a SNP rs2910164 (miR-146a rs2910164) in Tunisian patients with RA and their association with C reactive protein (CRP), rheumatoid factor (RF), anticyclic citrullinated peptide (anti-CCP) antibodies, and erosion.
|
28207326 |
2017 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this observational study, patients with untreated RA at risk of inadequate response to MTX included those with a higher TJC and higher CRP, while a higher TJC was the only independent predictor of an inadequate response to csDMARDs other than MTX.
|
30482075 |
2020 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In stratification analyses, a significantly increased risk for RA associated with the BLK rs2248932 CC genotype was evident among younger patients, CRP-negative patients and anti-CCP-positive patients compared with the BLK rs2248932 TT/TC genotype.
|
22740142 |
2012 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOMA2-IR indexes showed high values for both IR and beta cell production (%B), and low insulin sensitivity (%S) in patients with RA.C reactive protein (beta coef.
|
30299246 |
2019 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the stratification analyzes, a significantly increased risk for RA associated with the MIF -173 CC genotype was evident among CRP-negative patients compared with the MIF -173 GG/GC genotype.
|
22302395 |
2012 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings, together with the positive association between MBL variant alleles and the increased serum levels of IgM RF and CRP, point at the MBL gene as a relevant locus in the pathophysiology of RA.
|
11361219 |
2001 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference in age at onset, severity, functional class (> or = 3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms.
|
12455815 |
2002 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Following stratified analysis, an increased risk of RA was associated with the CC genotype among male, older, C-reactive protein-positive, anti-cyclic citrullinated peptide antibody-positive, and rheumatoid factor-positive-patients, and among patients with a DAS28 of≥3.20 or an erythrocyte sedimentation rate of≥25, and in functional class I and II patients.
|
25623518 |
2015 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SAA and C reactive protein (CRP) concentrations together with SAA1 genotypes were determined in 316 Japanese patients with RA.
|
11156544 |
2001 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In rheumatoid arthritis and lupus, genetic variants can restrict CRP elevations during flares.
|
29718222 |
2018 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A significantly positive correlation was observed between the SNP rs73013527 of ETS-1 and RA susceptibility, DAS28 and CRP (P<0.001, P = 0.001, and P = 0.028, respectively).
|
26241881 |
2015 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> Thirty-one patients with RA (22 women, age 62.4 years, disease duration 13.8 years, prior TCZ duration 35.7 months, 25 intravenous [8 mg/kg/4 weeks] and 6 subcutaneous [162 mg/2 weeks] TCZ treatments, concomitant MTX 8.5 mg/week [35.5%], and prednisolone (PSL) 4.3 mg/day [25.8%]) who showed an inadequate response to TCZ (disease activity score assessing 28 joints with C-reactive protein [DAS28-CRP] 2.9, clinical disease activity index [CDAI] 15.0, 28 secondary inadequate responders) were treated with additional IGU (final dose 41.7 mg/day) and enrolled in this 24-week, multicenter, retrospective study.
|
29882440 |
2019 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of RA susceptibility HLA-DRB1 amino acids with the C-reactive protein (CRP) level, the tender joint count (TJC), the swollen joint count (SJC), the Disease Activity Score in 28 joints (DAS28), and the Health Assessment Questionnaire (HAQ) score in the Norfolk Arthritis Register (NOAR) and Early Rheumatoid Arthritis Study (ERAS) cohorts.
|
27274008 |
2016 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In stratification analyses, a significantly increased risk for RA associated with the WDFY4 rs7097397 AG genotype was evident among female patients, younger patients, C-reactive protein (CRP) negative patients and both anti-cyclic citrullinated peptide antibody (ACPA) positive patients and negative patients compared with the WDFY4 rs7097397 AA genotype.
|
24549174 |
2014 |
|
Rheumatoid Arthritis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, the objective of this study was to determine the relation of BuChE phenotypes and PON-1 Q192R polymorphism with inflammatory markers such as anti-cytroline circulated peptide (CCP)-antibodies, CRP, neopterin, DAS28-CRP in RA patients.
|
25179377 |
2015 |
|
Rheumatoid Arthritis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP).
|
29644482 |
2018 |