|
Adenovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There were increased levels of HNP-1, -3, and -4, but not HNP-2, in nasal aspirates (NAs) during adenovirus infections compared to healthy specimens (<i>p</i> ≤ 0.01).
|
30154940 |
2018 |
|
Upper Respiratory Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate the release of HNP-1-4 in adenovirus infection and the relationship with self-limiting upper respiratory tract infections.
|
30154940 |
2018 |
|
Pancreatitis, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Spectrometry showed increased expression of HNP-1 in CP and even more in PDAC.
|
29683978 |
2018 |
|
Recurrent upper respiratory tract infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the release of HNP-1-4 in adenovirus infection and the relationship with self-limiting upper respiratory tract infections.
|
30154940 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Spectrometry showed increased expression of HNP-1 in CP and even more in PDAC.
|
29683978 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.
|
28420383 |
2017 |
|
Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively.
|
28449029 |
2017 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.
|
28420383 |
2017 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
At least one member of the defensin family was expressed in each tumor cell line, whereby α-defensin (DEFA1), DEFA2, or DEFA3 transcripts could be ubiquitously detected.
|
26711780 |
2016 |
|
Alzheimer disease, familial, type 3
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.
|
27082275 |
2016 |
|
Condylomata Acuminata
|
0.010 |
Biomarker
|
disease |
BEFREE |
The therapeutic impact of HNP-1 in condyloma acuminatum.
|
25600882 |
2015 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied.
|
25083086 |
2014 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied.
|
25083086 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients (117 patients with type 1 and 140 with type 2 diabetes).
|
25083086 |
2014 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A decreased gene expression of DEFA 1/3 and 4 might protect pleomorphic adenomas from malignant transformation into adenocarcinomas.
|
23050799 |
2012 |
|
Adenolymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A similar expression pattern of DEFA-1/3 and -4 in cystadenolymphomas and inflamed salivary glands underlines a potential importance of immunological reactions during the formation of Warthin's tumour.
|
23050799 |
2012 |
|
Behcet Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variable DEFA1 gene CNs were observed in both BD patients and HC and a high DEFA1 gene CN may be associated with susceptibility to intestinal involvement in BD.
|
22219625 |
2012 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In order to define new proliferation associated genes, purpose of this study was to investigate the expression of human α-defensins (DEFA) 1/3 and 4 in different tumour entities of the salivary glands with respect to malignancy.
|
23050799 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, higher expression of KLF9, SNAI1 and DEFA1 was found in ZZ COPD lungs without augmentation therapy relative to MM COPD or ZZ COPD with augmentation therapy.
|
22621770 |
2012 |
|
Mixed Salivary Gland Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A decreased gene expression of DEFA 1/3 and 4 might protect pleomorphic adenomas from malignant transformation into adenocarcinomas.
|
23050799 |
2012 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
In order to define new proliferation associated genes, purpose of this study was to investigate the expression of human α-defensins (DEFA) 1/3 and 4 in different tumour entities of the salivary glands with respect to malignancy.
|
23050799 |
2012 |
|
Neutrophilic asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Systemic expression of DEFA1,1B,3,4,CTSG and ELA2 was significantly higher in the neutrophilic asthma (NA) phenotype.
|
21785157 |
2011 |
|
Severe Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was designed to determine whether DEFA1/DEFA3 copy number variations conferred susceptibility to infection-induced complications such as severe sepsis.
|
20502117 |
2010 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sera from SLE patients and healthy controls were tested for pro-inflammatory human beta-defensin 2 (hBD-2) and for alpha-defensin human neutrophil peptide 1 (HNP-1). hBD-2 could not be detected by enzyme-linked immunosorbent assay (ELISA) and its mRNA levels were low in SLE patients and similar to those found in controls.
|
19191901 |
2009 |