DEFA1, defensin alpha 1, 1667

N. diseases: 57; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group LHGDN Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas. 18957723 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 Biomarker disease LHGDN Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy. 18003664 2008
CUI: C0023223
Disease: Leg Ulcer
Leg Ulcer 		0.010 AlteredExpression disease LHGDN Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers. 18472248 2008
CUI: C0085166
Disease: Bacterial Vaginosis
Bacterial Vaginosis 		0.010 AlteredExpression disease LHGDN Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery. 18757648 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 AlteredExpression phenotype BEFREE Loss of HP1 proteins causes chromosome segregation defects and lethality in some organisms; a reduction in levels of HP1 family members is associated with cancer progression in humans. 18926834 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE Alpha-defensins 1-3 (human neutrophil peptides [HNP]1-3), reported to be elevated in tumor tissue and serum of patients with colorectal cancer (CRC), have not been studied in stool. 17531545 2007
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease LHGDN Treatment of cell cultures with HNP-1 soon after infection resulted in marked inhibition of influenza virus replication and viral protein synthesis. 17703413 2007
CUI: C0035243
Disease: Respiratory Tract Infections
Respiratory Tract Infections 		0.010 GeneticVariation group LHGDN Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. 16700921 2006
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 Biomarker disease BEFREE Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins. 15507473 2005
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 Biomarker phenotype LHGDN Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. 15208269 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 Biomarker disease LHGDN Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis. 12913926 2003
CUI: C0015929
Disease: Fetal Diseases
Fetal Diseases 		0.010 AlteredExpression group LHGDN Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes. 12710851 2003
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.010 Biomarker disease BEFREE Cellular necrosis observed in RCC tissues in association with extensive patches of HNP-1, -2, and -3, seemed to be related to high concentrations of alpha-defensins. 11943716 2002
CUI: C0851887
Disease: Adenoviral infections
Adenoviral infections 		0.010 Biomarker group BEFREE Compared to control, HNP-1 reduced adenoviral infection by more than 95% if administered at 50 microg/ml, and the IC50-value was 15 microg/ml. 11495691 2001
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.010 Biomarker disease BEFREE The frequency of the Hp-1 gene was significantly greater in the patients with major depression (48.6%) than in the normal population (39.0%). 8267107 1994
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.010 Biomarker disease BEFREE The frequency of the Hp-1 gene was significantly greater in the patients with major depression (48.6%) than in the normal population (39.0%). 8267107 1994
CUI: C0023474
Disease: Leukemia, Myeloid, Chronic-Phase
Leukemia, Myeloid, Chronic-Phase 		0.010 Biomarker disease BEFREE This myeloid-related sequence (mrs) comprises approximately 2% of the chronic phase, CML mRNA. 2893504 1987