|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The SNP rs3910901, located in the 5' upstream region of ELF5, was found to have a weak association (p = 0.043) with asthma in the odds ratio analysis.
|
25648666 |
2016 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage studies suggest that ESE-2 and ESE-3, which encode epithelium-specific Ets-domain-containing transcription factors, are candidate asthma susceptibility genes.
|
18475289 |
2008 |
|
Benign epithelial tumor of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues.
|
28184931 |
2017 |
|
Borderline epithelial tumor of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues.
|
28184931 |
2017 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer.
|
23086238 |
2012 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Thus ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells and promotion of basal characteristics in basal breast cancer cells, an action that may be utilised to acquire antiestrogen resistance.
|
23300383 |
2012 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
ELF5 levels are low in airway cells but higher in LNCaP (prostate) and T47D (breast) cancer cells.
|
31557407 |
2019 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Four genes, Ehf, Elf3, Elf5 and Pdef, were expressed at higher levels in breast cancer cells than normal epithelials.
|
17172821 |
2007 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
|
26717410 |
2015 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 also plays key roles in malignancy, particularly in basal-like and endocrine-resistant forms of breast cancer.
|
26738740 |
2016 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer.
|
25629735 |
2015 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5; depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.
|
31376015 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that ELF5 may play roles in mammary, lung, prostate and/or kidney function, and possibly also in tumorigenesis.
|
9840936 |
1998 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
In our cohort, 47% of all carcinomas were positive for Elf5, with a significantly higher proportion of Elf5 positive cases occurring in the younger age groups (p = 0.0061).
|
29396764 |
2018 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
ELF5 mRNA was decreased in 94% of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas.
|
21787113 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues.
|
28184931 |
2017 |
|
Congenital chromosomal disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The finding of acquired clonal chromosome abnormalities in cells cultured from the lesion and the presence of the TNS3-MAP3K3 chimeric protein kinase and the ZFPM2-ELF5 chimeric transcription factor confirm the neoplastic nature of multicystic mesothelioma.
|
25484136 |
2015 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal.
|
21787113 |
2011 |
|
Cystic Fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
E74-like factor 5 (ELF5) and ETS-homologous factor (EHF) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity.
|
31557407 |
2019 |
|
Eclampsia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our identification of the trophoblast-specific transcriptional circuit established by ELF5 will be instrumental to derive human TS cell lines that truly reflect early placental trophoblast and that will be most beneficial to gain insights into the aetiology of common pregnancy complications, including intra-uterine growth restriction and pre-eclampsia.
|
20354077 |
2010 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ELF5 was in accordance with the International Federation of Gynecology and Obstetrics (FIGO) staging of endometrial carcinoma (P<0.05), pathological grading (P<0.05), pathological typing (P=0.001), state of lymph node metastasis (P<0.05) and depth of myometrial invasion (P<0.05).
|
30127951 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that IUGR and GD are associated with significantly increased levels of ELF5 protein in placentas, which suggests that ELF5 may play an important role in normal placentation.
|
27384067 |
2017 |
|
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that IUGR and GD are associated with significantly increased levels of ELF5 protein in placentas, which suggests that ELF5 may play an important role in normal placentation.
|
27384067 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.
|
27627705 |
2016 |
|
Luminal A Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
As ELF5 has been previously implicated in the development of antiestrogen resistance, this finding implicates ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
|
26717410 |
2015 |