ELF5, E74 like ETS transcription factor 5, 2001

N. diseases: 34; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE Our data suggest that ELF5 may play roles in mammary, lung, prostate and/or kidney function, and possibly also in tumorigenesis. 9840936 1998
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 AlteredExpression disease BEFREE Four genes, Ehf, Elf3, Elf5 and Pdef, were expressed at higher levels in breast cancer cells than normal epithelials. 17172821 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 AlteredExpression disease BEFREE Four genes, Ehf, Elf3, Elf5 and Pdef, were expressed at higher levels in breast cancer cells than normal epithelials. 17172821 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.020 GeneticVariation disease BEFREE Genetic linkage studies suggest that ESE-2 and ESE-3, which encode epithelium-specific Ets-domain-containing transcription factors, are candidate asthma susceptibility genes. 18475289 2008
CUI: C0013537
Disease: Eclampsia
Eclampsia 		0.010 Biomarker disease BEFREE Our identification of the trophoblast-specific transcriptional circuit established by ELF5 will be instrumental to derive human TS cell lines that truly reflect early placental trophoblast and that will be most beneficial to gain insights into the aetiology of common pregnancy complications, including intra-uterine growth restriction and pre-eclampsia. 20354077 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE This work is the first to suggest that ELF5 has tumor suppressor activity in the kidney. 21787113 2011
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE ELF5 mRNA was decreased in 94% of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas. 21787113 2011
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.010 AlteredExpression disease BEFREE In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal. 21787113 2011
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.010 AlteredExpression disease BEFREE In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal. 21787113 2011
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.010 AlteredExpression disease BEFREE Since ELF5 is highly expressed in kidney and has been postulated to function as a tumor suppressor, at least in the context of the breast, we investigated its role in kidney cancer. 21787113 2011
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.010 AlteredExpression disease BEFREE Since ELF5 is highly expressed in kidney and has been postulated to function as a tumor suppressor, at least in the context of the breast, we investigated its role in kidney cancer. 21787113 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. 23086238 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. 23086238 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. 23086238 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 AlteredExpression group BEFREE The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis. 23131919 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis. 23131919 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 AlteredExpression disease BEFREE Thus ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells and promotion of basal characteristics in basal breast cancer cells, an action that may be utilised to acquire antiestrogen resistance. 23300383 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 AlteredExpression disease BEFREE Thus ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells and promotion of basal characteristics in basal breast cancer cells, an action that may be utilised to acquire antiestrogen resistance. 23300383 2012
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 AlteredExpression group BEFREE The finding of acquired clonal chromosome abnormalities in cells cultured from the lesion and the presence of the TNS3-MAP3K3 chimeric protein kinase and the ZFPM2-ELF5 chimeric transcription factor confirm the neoplastic nature of multicystic mesothelioma. 25484136 2015
CUI: C0206680
Disease: Mesothelioma, Cystic
Mesothelioma, Cystic 		0.010 AlteredExpression disease BEFREE The finding of acquired clonal chromosome abnormalities in cells cultured from the lesion and the presence of the TNS3-MAP3K3 chimeric protein kinase and the ZFPM2-ELF5 chimeric transcription factor confirm the neoplastic nature of multicystic mesothelioma. 25484136 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. 25629735 2015
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. 25629735 2015