ELF5, E74 like ETS transcription factor 5, 2001

N. diseases: 34; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE ELF5 mRNA was decreased in 94% of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas. 21787113 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. 25629735 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. 26717410 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. 26717410 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE ELF5 also plays key roles in malignancy, particularly in basal-like and endocrine-resistant forms of breast cancer. 26738740 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE ELF5 also plays key roles in malignancy, particularly in basal-like and endocrine-resistant forms of breast cancer. 26738740 2016
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.010 AlteredExpression disease BEFREE ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues. 28184931 2017
CUI: C3665489
Disease: Borderline epithelial tumor of ovary
Borderline epithelial tumor of ovary 		0.010 AlteredExpression disease BEFREE ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues. 28184931 2017
CUI: C0346168
Disease: Benign epithelial tumor of ovary
Benign epithelial tumor of ovary 		0.010 AlteredExpression disease BEFREE ELF5 mRNA in epithelial ovarian carcinoma and borderline ovarian epithelial tumor tissues were significantly lower (P<0.05) than those in benign ovarian epithelial tumor and normal ovarian tissues. 28184931 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Elf5 is a transcription factor known to regulate critical developmental processes and has been shown to act as a tumour suppressor in multiple cancers. 31002388 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.010 GeneticVariation disease BEFREE E74-like factor 5 (ELF5) and ETS-homologous factor (EHF) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity. 31557407 2019
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.010 Biomarker group BEFREE E74-like factor 5 (ELF5) and ETS-homologous factor (EHF) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity. 31557407 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 AlteredExpression disease BEFREE ELF5 levels are low in airway cells but higher in LNCaP (prostate) and T47D (breast) cancer cells. 31557407 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 AlteredExpression disease BEFREE ELF5 levels are low in airway cells but higher in LNCaP (prostate) and T47D (breast) cancer cells. 31557407 2019
CUI: C3642345
Disease: Luminal A Breast Carcinoma
Luminal A Breast Carcinoma 		0.010 Biomarker disease BEFREE As ELF5 has been previously implicated in the development of antiestrogen resistance, this finding implicates ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer. 26717410 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE BACKGROUND E74-like factor 5 (ELF5) plays a key role in the processes of cell differentiation, apoptosis, and occurrence of tumors. 30696803 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 AlteredExpression disease BEFREE Downregulation of ELF5 by shRNA increases the expression of AR-response genes and the progression of PCa. 28287091 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 AlteredExpression disease BEFREE Downregulation of ELF5 by shRNA increases the expression of AR-response genes and the progression of PCa. 28287091 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression phenotype BEFREE Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5; depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3. 31376015 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 AlteredExpression phenotype BEFREE Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5; depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3. 31376015 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. 25629735 2015
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer. 25629735 2015
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway. 27627705 2016