|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
ELF5 levels are low in airway cells but higher in LNCaP (prostate) and T47D (breast) cancer cells.
|
31557407 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Elf5 is a transcription factor known to regulate critical developmental processes and has been shown to act as a tumour suppressor in multiple cancers.
|
31002388 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
BACKGROUND E74-like factor 5 (ELF5) plays a key role in the processes of cell differentiation, apoptosis, and occurrence of tumors.
|
30696803 |
2019 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
ELF5 levels are low in airway cells but higher in LNCaP (prostate) and T47D (breast) cancer cells.
|
31557407 |
2019 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 also plays key roles in malignancy, particularly in basal-like and endocrine-resistant forms of breast cancer.
|
26738740 |
2016 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The injection of EWSR1/ELF5-transduced NIH3T3 cells into NSG-SCID mice systematically induced the development of tumors in vivo.
|
27627705 |
2016 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 also plays key roles in malignancy, particularly in basal-like and endocrine-resistant forms of breast cancer.
|
26738740 |
2016 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
|
26717410 |
2015 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer.
|
25629735 |
2015 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Myeloid-derived suppressor cells, a group of immature neutrophils recently identified as mediators of vasculogenesis and metastasis, were recruited to the tumor in response to ELF5.
|
26717410 |
2015 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer.
|
25629735 |
2015 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
|
26717410 |
2015 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer.
|
25629735 |
2015 |
|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Thus ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells and promotion of basal characteristics in basal breast cancer cells, an action that may be utilised to acquire antiestrogen resistance.
|
23300383 |
2012 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer.
|
23086238 |
2012 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.
|
23131919 |
2012 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer.
|
23086238 |
2012 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Thus ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells and promotion of basal characteristics in basal breast cancer cells, an action that may be utilised to acquire antiestrogen resistance.
|
23300383 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
This work is the first to suggest that ELF5 has tumor suppressor activity in the kidney.
|
21787113 |
2011 |
|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Four genes, Ehf, Elf3, Elf5 and Pdef, were expressed at higher levels in breast cancer cells than normal epithelials.
|
17172821 |
2007 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Four genes, Ehf, Elf3, Elf5 and Pdef, were expressed at higher levels in breast cancer cells than normal epithelials.
|
17172821 |
2007 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
However, the effect of ELF5 on metastasis and invasion in human ovarian cancer remains poorly understood.
|
30696803 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The transcription factor E74-like factor 5 (ELF5) is a potent antioncogene that can prevent epithelial-mesenchymal transition (EMT) and metastasis in prostate cancer (PCa).
|
28287091 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, in the MMTV-PyMT mouse mammary model, increased ELF5 levels drive metastasis by co-opting the innate immune system.
|
26717410 |
2015 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.
|
23131919 |
2012 |