|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we found a WDR48 somatic mutation (L580F) that is defective in stabilizing PHLPP1 in colorectal cancers, supporting a WDR48 role in tumor suppression.
|
24145035 |
2013 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Microarray datasets of colorectal tumor and nontumor tissues were analyzed for PHLPP gene expression.
|
24530606 |
2014 |
|
Coronary Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
|
29940243 |
2018 |
|
Degenerative polyarthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Altered Phlpp1 levels are associated with cancer and degenerative diseases such as osteoarthritis.
|
29775231 |
2018 |
|
Degenerative polyarthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis.
|
29068480 |
2018 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The second group was treated with SCOP to induce dementia.
|
27631101 |
2017 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, the levels of one isozyme, PHLPP1, are elevated in diabetes.
|
27913677 |
2016 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Conversely, the levels of one isozyme, PHLPP1, are elevated in diabetes.
|
27913677 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
PHLPP: a putative cellular target during insulin resistance and type 2 diabetes.
|
28428363 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results suggest that several mechanisms affecting Akt isoforms, including deregulated production of PHLPP1, could underlie the alterations of skeletal muscle insulin signalling in type 2 diabetes.
|
18204829 |
2008 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that PHLPP1 up-surged Nrf2 nuclear instability by promoting Nrf2/β-TrCP association and its inhibition may be critical in the management of diabetic nephropathy.
|
29655866 |
2018 |
|
Diabetic Nephropathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
|
Gallbladder Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SNORA74B expression was positively associated with local invasion, advanced TNM stage, CA19-9 level, and Ki67 expression in patients with GBC, while it was negatively associated with expression of PHLPP, an endogenous Akt inhibitor.
|
28212545 |
2017 |
|
Gallbladder Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Increasing PHLPP expression or inhibiting miR-495 expression can induce apoptosis and suppress tumor growth in GBC xenograft model in nude mice.
|
25895131 |
2015 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The highest mean values of PHLPP1 mRNA and protein were found in non-glioma brain tissues whereas the lowest mean values were found in those in glioblastoma with an increase of TNF-α, IL-17, IL-1β (p<0.05).
|
26971226 |
2016 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoring the localization of β-TrCP1 to the cytosol of glioblastoma cells rescues the ability of Akt to regulate PHLPP1 stability.
|
21454620 |
2011 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The highest mean values of PHLPP1 mRNA and protein were found in non-glioma brain tissues whereas the lowest mean values were found in those in glioblastoma with an increase of TNF-α, IL-17, IL-1β (p<0.05).
|
26971226 |
2016 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoring the localization of β-TrCP1 to the cytosol of glioblastoma cells rescues the ability of Akt to regulate PHLPP1 stability.
|
21454620 |
2011 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that PHLPP1 played a suppression role in inflammatory response of glioma.
|
26971226 |
2016 |
|
Gram-Negative Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These data highlight a link between leptin signaling, the mTORC2/Phlpp1/Akt axis, and lysosomal activity in macrophages and have important therapeutic implications for modulating innate immunity to combat Gram-negative bacterial infections.
|
31350351 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report a critical role of lncRNA PCAT1 in regulating the PHLPP/FKBP51/IKKα complex and progression of castration-resistant prostate cancer (CRPC).
|
30773595 |
2019 |
|
Huntington Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results show decreased PHLPP1 protein levels in knock-in models (Hdh(Q111/Q111) mouse striatum and STHdh(Q111/Q111) cells), in the striatum of N-terminal exon-1 mutant huntingtin transgenic mouse models (R6/1; R6/1 : BDNF + or - , R6/2 and Tet/HD94) and in the putamen of HD patients.
|
19745829 |
2010 |
|
Hyperglycemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene knockdown of PHLPP1 in NRK52E cells enhanced Nrf2-responsive antioxidant enzymes HO-1 and NQO-1 which suggested that PHLPP1 up-regulation during hyperglycemia lowers Nrf2 stability via GSK3β activation.
|
29655866 |
2018 |