Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692). 19337309 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway. 18946483 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12). 19834503 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease LHGDN Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway. 18946483 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease BEFREE To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. 19375175 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 GeneticVariation disease BEFREE We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). 19525955 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease CTD_human Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway. 18946483 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.500 Biomarker disease CTD_human We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). 19525955 2009