|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK).
|
30900517 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization confirmed the existence of ALK rearrangement in IMT tissues.
|
28923119 |
2017 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that a subset of ALK-negative IMTs have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism, and that the detection of these alterations may be of diagnostic value and helpful for determining promising therapeutic strategies.
|
26647767 |
2016 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Approximately half of the inflammatory myofibroblastic tumors contain translocations that result in the over-expression of the anaplastic lymphoma kinase (ALK) gene.
|
28409069 |
2017 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
We suggest that chromosomal rearrangements involving 2p23 near or within ALK are recurrent alterations in IMT and that ALK may have a novel role outside its previously recognized realm of lymphoid neoplasms.
|
10383129 |
1999 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To investigate the utility of detecting anaplastic lymphoma kinase-1 protein expression and ALK gene rearrangements in the diagnosis of inflammatory myofibroblastic tumors in the female genital tract.
|
22646268 |
2012 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK positivity was observed in 17 of 47 IMTs (36%) and p80 positivity in 16 of 47 IMTs (34%).
|
11406658 |
2001 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
We describe an inflammatory myofibroblastic tumor in the lower abdominal wall of an adult male, which occurred 88days after he received an allogeneic stem cell transplant for T-lymphoblastic lymphoma, and which was positive for ALK immunohistochemistry and showed ALK gene rearrangement by fluorescence in situ hybridization.
|
27155927 |
2016 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
We advocate scrutinizing patients with presumptive single organ IgG4-RD for IMT and the diagnostic algorithm should include ALK and ROS1 immunohistochemistry and, in selected cases, a next-generation sequencing-based fusion assay that covers known IMT-associated gene fusions.
|
30451733 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Epithelioid inflammatory myofibroblastic sarcoma is a variant of inflammatory myofibroblastic tumor with aggressive clinical course associated with RANBP2-ALK fusion.
|
25028698 |
2014 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors.
|
17656252 |
2007 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor.
|
17063337 |
2007 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All 14 IMTs were confirmed to harbor ALK genetic fusion by RNA sequencing, and ALK immunostaining in the form of granular cytoplasmic positivity with paranuclear accentuation was observed in all 14 cases.
|
30015720 |
2018 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK and cytokeratin, when positive, can be helpful in differentiating IMT from LGMS.
|
18400254 |
2008 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Some populations of IMT have anaplastic large cell lymphoma kinase (ALK) gene rearrangements.
|
16984614 |
2006 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Even on re-review the IMT in these 2 cases were morphologically indistinguishable from other cases of IMT, with FISH demonstrating ALK alterations in the IMT areas in one of them.
|
17122505 |
2006 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal translocations leading to activation of the ALK tyrosine kinase can be detected in approximately 50% of IMTs, particularly those arising in young patients.
|
17938159 |
2008 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK is a receptor tyrosine kinase, associated with many tumor types as diverse as anaplastic large cell lymphomas, inflammatory myofibroblastic tumors, breast and renal cell carcinomas, non-small cell lung cancer, neuroblastomas, and more.
|
30813562 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that ALK expression in AFH is common, particularly with the highly sensitive D5F3 and 5A4 antibodies and enhanced detection systems, and may be a potential source of diagnostic confusion with IMT.
|
29877921 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Further review revealed that although a diagnosis of IMT was considered for the ALK immunopositive myxoid leiomyoma, this diagnosis was not initially rendered only because fluorescence in situ hybridization analysis was interpreted as negative for ALK genetic rearrangement; this case is best reclassified as an IMT.
|
28490045 |
2017 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Crizotinib, a first-generation ALK inhibitor, has been shown to have a notable response in patients with ALK-positive IMT.
|
30790150 |
2019 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus, ALK reactivity may be a favorable prognostic indicator in IMT and abdominopelvic IMTs recur more frequently.
|
17414097 |
2007 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
The genetic hallmark of IMT is ALK rearrangement from chromosome arm 2p, but gene mutations involved in IMT remain poorly understood.
|
25120743 |
2014 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor of the lung in children: anaplastic lymphoma kinase (ALK) expression and clinico-pathological correlation.
|
22280150 |
2012 |
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?
|
11284039 |
2001 |