|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1.
|
30924128 |
2019 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma.
|
14712484 |
2004 |
|
Adult Glioblastoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The Ang-(1-7) was proven to have an inhibitory effect on glioblastoma growth.
|
30229380 |
2019 |
|
Adult Glioblastoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Whereas Ang-1 mRNA was expressed in tumor cells, Ang-2 mRNA was detected in endothelial cells of a subset of glioblastoma blood vessels.
|
9811337 |
1998 |
|
Advanced Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that Ang-(1-7) may have therapeutic potential against advanced lung carcinoma as a new agent.
|
22089256 |
2012 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
By applying AprioriGWAS to age-related macular degeneration (AMD) data, we found that: (1) angiopoietin 1 (ANGPT1) and four retinal genes interact with Complement Factor H (CFH).
|
24901472 |
2014 |
|
AIDS with Kaposi's sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous angiosarcomas, and in normal skin.
|
10854238 |
2000 |
|
Alveolar Bone Loss
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, Ang-(1-7) and DIZE decreased alveolar bone loss through improvement of osteoblast/osteoclast ratio.A-779 reversed such phenotype.
|
31442676 |
2019 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
CSF Ang-I, Ang-II, and Ang-(1-7) levels were unchanged in AD.
|
31594235 |
2019 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Finally, we show that the ratio of Ang II to Ang (1-7) (a proxy measure of ACE-2 activity indicating conversion of Ang II to Ang (1-7)) is reduced in AD.
|
27884212 |
2016 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, dimenazine-induced stimulation of ACE2/Ang(1-7)/Mas axis subdues cognitive deficits in AD most probably through activation of PI3K/Akt pathway.
|
29516284 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model.
|
30476904 |
2018 |
|
Amyotrophic Lateral Sclerosis, Guam Form
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, angiopoietin-1, an endothelial growth factor crucial for vascular development and angiogenesis, and the integrin αvβ3 binding peptide C16, which inhibits inflammatory cell infiltration, were utilized to improve the local microenvironment within the central nervous system of an ALS/PDC rodent model by minimizing inflammation.
|
30476904 |
2018 |
|
anaphylaxis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results of our study reveal, for the first time, the important role of Ang-1 in the activation of mast cells, and identify a therapeutic effect of Ang-1 on anaphylaxis diseases.
|
24586553 |
2014 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
VSMC dedifferentiation is a feature of early SpA remodelling and uNK cells and EVT play key roles in this process by secretion of Ang-1 and Ang-2.
|
31348822 |
2019 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These data support the evidence that the reversal of Ang-1 and Ang-2 expression plays an important role in the angiogenic and dedifferentiation processes in HCC.
|
14600132 |
2003 |
|
Angioedemas, Hereditary
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The ANGPT1 p.A119S variant was detected in all members of the index family with U-HAE but not in asymptomatic family members or an additional 20 patients with familial U-HAE, 22 patients with sporadic U-HAE, and 200 control subjects.
|
28601681 |
2018 |
|
Angioedemas, Hereditary
|
0.040 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema.
|
30689269 |
2019 |
|
Angioedemas, Hereditary
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The recent discovery of associations between PLG K330E and ANGPT1 A119S and HAE of unknown genetic cause (HAE-U), has raised the possibility that genetic evaluation could be used to diagnose HAE-U in patients with unexplained angioedema or non-confirmatory laboratory testing.
|
31131012 |
2019 |
|
Angioedemas, Hereditary
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Most disease-causing variants lie within the SERPING1 gene, while FXII12, PLG and ANGPT1 gene variants are also reported to associate with HAE.
|
30827947 |
2019 |
|
Angiogenic Switch
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch.
|
21233403 |
2011 |
|
Angioimmunoblastic Lymphadenopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Angiogenic mediators angiopoietin (Ang) 1 (ANGPT1), Ang2 (ANGPT2) and their receptor, Tie2 (TEK), vascular endothelial growth factor (VEGF; VEGFA) and its receptor, VEGFR2 (KDR), and hepatocyte growth factor (HGF) and its receptor, c-Met (MET) were all more highly expressed in AILT lymph nodes (16 cases) than in B-cell lymphomas (24 cases).
|
19120365 |
2009 |
|
Anoxia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis.
|
15198927 |
2004 |
|
Anxiety and fear
|
0.010 |
Biomarker
|
disease |
BEFREE |
More recently, Ang-(1-7) has also been implicated in the control of emotional states related to fear and anxiety.
|
28502733 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ang-(1-7) treatment attenuated Ang II-induced AAA via inhibiting vascular inflammation, extracellular matrix degradation and SMCs apoptosis.
|
31658493 |
2020 |