ANGPT1, angiopoietin 1, 284

N. diseases: 340; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.050 AlteredExpression disease BEFREE Ang1 expression was found in a few astrocytes scattered in the tumor at all stages of astrocytoma progression. 11304469 2001
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 AlteredExpression disease BEFREE Ang1 expression was found in a few astrocytes scattered in the tumor at all stages of astrocytoma progression. 11304469 2001
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.050 AlteredExpression disease BEFREE In this study, we demonstrate that the angiopoietin family member Ang1 is expressed by some of the astrocytoma cell lines. 11305411 2001
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 AlteredExpression disease BEFREE In this study, we demonstrate that the angiopoietin family member Ang1 is expressed by some of the astrocytoma cell lines. 11305411 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 AlteredExpression disease BEFREE Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. 11309342 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE There was a significant reduction in expression of tumor Ang-1 (P = 0.04), Ang-2 (P = 0.01), Ang-4 (P = 0.004), and Tie2 (P = 0.02) compared with that in normal breast tissues. 11309342 2001
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 AlteredExpression disease BEFREE Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. 11309342 2001
CUI: C3714757
Disease: Juvenile rheumatoid arthritis
Juvenile rheumatoid arthritis 		0.010 AlteredExpression disease BEFREE Detectable levels of messenger RNA for vascular endothelial growth factor and angiopoietin 1 and their respective receptors, as well as endoglin and thrombin receptors, were present in all JRA tissue specimens studied. 11315918 2001
CUI: C0018021
Disease: Goiter
Goiter 		0.010 AlteredExpression phenotype BEFREE In an induced goiter in rats, in situ hybridization showed increased expression of messenger ribonucleic acids (mRNAs) for Tie-2 and Ang-1 in follicular cells. 11397875 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.100 AlteredExpression group BEFREE We hypothesized that aberrant expression of the angiopoietin-1 gene in the adult lung would be a major contributing factor in the development of pulmonary hypertension. 11436038 2001
CUI: C0036572
Disease: Seizures
Seizures 		0.010 AlteredExpression phenotype BEFREE We examined mRNA and protein expression of angiopoietin 1 (Ang1) and Ang2 by semiquantitative reverse transcriptase-polymerase chain reaction, in situ hybridization, and Western blot in BAVMs and control brains obtained from temporal lobectomy for medically intractable seizures. 11463715 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Immunofluorescent staining (n = 20 specimens) revealed the presence of Ang-2 protein in normal mucosa and tumor epithelium, but Ang-1 was expressed only in normal mucosa. 11571726 2001
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 AlteredExpression disease BEFREE Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses and immunofluorescent double-staining were performed to examine human colon carcinoma cell lines, surgical specimens, normal mucosa, and liver metastases for the expression of Ang-1 and Ang-2. 11571726 2001
CUI: C0494165
Disease: Secondary malignant neoplasm of liver
Secondary malignant neoplasm of liver 		0.010 AlteredExpression disease BEFREE Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses and immunofluorescent double-staining were performed to examine human colon carcinoma cell lines, surgical specimens, normal mucosa, and liver metastases for the expression of Ang-1 and Ang-2. 11571726 2001
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE Although Ang1 is expressed constitutively in many adult tissues, its role in tumor growth and metastasis is not clear. 11668472 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Our results indicate that the perturbation of Ang1 expression in tumors could be an effective method to control tumor growth by inhibiting tumor angiogenesis and that antisense RNA is an efficient way to inhibit Ang1 protein production in tumor cells. 11668472 2001
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Our results indicate that the perturbation of Ang1 expression in tumors could be an effective method to control tumor growth by inhibiting tumor angiogenesis and that antisense RNA is an efficient way to inhibit Ang1 protein production in tumor cells. 11668472 2001
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.010 Biomarker group BEFREE The modified HeLa cells produced significantly less Ang1 protein both in cultured cells and in tumors formed when these cells were injected into immunodeficient mice. 11668472 2001
CUI: C0018916
Disease: Hemangioma
Hemangioma 		0.010 Biomarker disease BEFREE We found Tie2 mRNA and protein up-regulated with a concomitant increase in cellular responsiveness to Ang1 in most hemangioma-derived endothelial cells. 11733376 2001
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia 		0.010 AlteredExpression disease BEFREE Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid leukemia. 11755466 2002
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.290 Biomarker group RGD In addition, expression of angiopoietin-1 and the angiopoietin receptor dropped markedly after stroke in SHRSP animals, but was not different after ischemia in SHR and WKY strains. 11822892 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.060 AlteredExpression disease BEFREE Ang-1 was the most highly expressed ligand in late stage RA synovial fibroblasts; however, in chronic inflamed synovial tissue, Ang-2 was predominant and was expressed at strikingly high levels (70 to 120-fold increase). 11838839 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE The levels of vascular endothelial growth factor (VEGF), its receptors VEGFR1 and VEGFR2, and angiopoietin-1 mRNA tended to be higher in the mammary fat pad tumors than in the cranial tumors (1.5-, 1.5-, 3-, and 2-fold, respectively). 11948107 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE In addition, to additionally investigate the issue of tumor dormancy we wished to assess the relationship between Mcm2 labeling index (LI) and the angiogenic factors angiopoietin-1 (Ang) and Ang-2. 11948116 2002
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.060 AlteredExpression disease BEFREE In conclusion, the dominance of Ang-1 mRNA and protein expression over Ang-2 is in agreement with an active neovascularization in RA synovial tissue. 12010571 2002