CXCL1, C-X-C motif chemokine ligand 1, 2919

N. diseases: 315; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0241868
Disease: acute aortic dissection
acute aortic dissection 		0.010 Biomarker disease BEFREE Interference of CXCL1 function using an anti-CXCR2 antibody reduced neutrophil accumulation and limited aortic rupture post AAD. 25563839 2015
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 Biomarker disease BEFREE Peripheral blood leucocyte subsets, cell adhesion molecules, high-sensitivity C reactive protein (hs-CRP), the monocyte and neutrophil chemoattractants CCL2 and CXCL1, CXCL5, respectively were measured in the blood of patients who received either intracoronary sodium nitrite (N=40) or placebo (N=40) during PPCI for AMI. 27683405 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.010 AlteredExpression disease BEFREE Concordantly, expression of AP-induced STAT3-responsive chemokines, especially monocyte chemotactic protein-1 (MCP-1) and chemokine (C-X-C motif) ligand 1 (CXCL1) was reduced, thereby contributing to modulated pancreatic immune milieu. 31726046 2020
CUI: C0520575
Disease: Acute pyelonephritis
Acute pyelonephritis 		0.010 Biomarker disease BEFREE Lactoferrin (LTF) and CXCL1 were higher in APN and NP. 27352120 2016
CUI: C0431129
Disease: Adamantinous Craniopharyngioma
Adamantinous Craniopharyngioma 		0.010 Biomarker disease BEFREE For neutrophil chemotactic factor, significant increases of IL-8 and GRO were observed in ACP, but for eosinophil chemotactic factor, no difference was found in RANTES and GM-CSF. 31249603 2019
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.010 Biomarker disease BEFREE Finally, we identified that growth-regulated oncogene-α (GRO-α) secreted by Caco-2 cells was a factor facilitating flagellar filament rotation and swarming motility, although it did not attract the bacteria. 28983473 2017
CUI: C0001430
Disease: Adenoma
Adenoma 		0.020 AlteredExpression group BEFREE In thyroid autonomy (n=10), the GRO-alpha mRNA levels were significantly lower in autonomous single adenomas compared with the corresponding normal tissue. 11524231 2001
CUI: C0001430
Disease: Adenoma
Adenoma 		0.020 Biomarker group BEFREE In situ hybridization for two selected transcripts (CA7, CXCL1) was performed on NAT (n = 3), adenoma (n = 3) and CRC (n = 3) FFPE samples. 26208990 2015
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 AlteredExpression disease BEFREE In situ hybridization could confirm the upregulation of CXCL1 and downregulation of CA7 in colorectal adenomas and tumors compared to healthy controls. 26208990 2015
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 AlteredExpression disease BEFREE Our results demonstrate a significant association between CXCL1 and CXCL5 expression with CRC and CRLM suggesting for both chemokine ligands a potential role in the progression from CRA to CRC and thus, in the initiation of CRC. 18578857 2008
CUI: C1282239
Disease: Adenoviral keratitis
Adenoviral keratitis 		0.010 Biomarker disease BEFREE Here, we have characterized the role of chemokine CXCL1/KC and receptor CXCR2 in adenoviral keratitis using a novel mouse model. 19642907 2009
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.010 Biomarker disease BEFREE Mean concentrations of cytokines in aqueous humour in patients with neovascular AMD before the first and third ranibizumab injections were as follows (in pg/mL): CXCL1, 8.4 and 3.3; IP-10, 110 and 55; CXCL12, 480 and 240; CXCL13, 9.2 and 2.6; MCP-1, 620 and 220; CCL11, 7.1 and 2.8; IL-6, 5.9 and 1.6; IL-10, 0.15 and 0.015 (all p<0.0001), and MMP-9, 0.92 and 1.5 (p=0.0216), respectively. 28765149 2018
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.210 Biomarker group BEFREE Increased production of interleukin-8 and CXCL1 by hepatocytes carrying the PNPLA3 148M variant contributes to a pro-inflammatory and tumorigenic milieu in patients with alcoholic liver disease. 31637480 2019
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.210 Biomarker group RGD Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. 10498645 1999
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		0.300 Biomarker phenotype CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0002170
Disease: Alopecia
Alopecia 		0.010 GeneticVariation disease BEFREE Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population. 26345899 2015
CUI: C0002171
Disease: Alopecia Areata
Alopecia Areata 		0.010 GeneticVariation disease BEFREE Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population. 26345899 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population. 15843053 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 AlteredExpression disease BEFREE Furthermore, monocytes derived from a transgenic mouse model of AD also expressed significantly higher CXCL1. 23967336 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 Biomarker disease BEFREE We used APP/PS1 mice and neural stem cells to elucidate the role of CXCL1 in Alzheimer's disease. 31146911 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.010 Biomarker disease BEFREE Our data suggest that the TLR and NLR signaling pathways are involved in pathological innate immunity and neuroinflammation associated with ALS and that TOLLIP, MAPK9, IL-1β, IL-8, and CXCL1 play a role in ALS-specific immune responses. 27812125 2016
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.010 Biomarker disease BEFREE Targeted inhibition of CXCL1 and/or CXCR2 may therefore represent a new therapeutic approach for acute VOC in SCD patients. 21383500 2011
CUI: C1832661
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
ANOPHTHALMIA AND PULMONARY HYPOPLASIA 		0.010 Biomarker disease BEFREE (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy. 30021140 2018
CUI: C0003496
Disease: Aortic Rupture
Aortic Rupture 		0.010 Biomarker disease BEFREE Interference of CXCL1 function using an anti-CXCR2 antibody reduced neutrophil accumulation and limited aortic rupture post AAD. 25563839 2015
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 AlteredExpression disease BEFREE Taken together, the present study indicates that IL-33 localized in the human atherosclerotic plaque increases GRO-α mRNA expression and protein secretion via activation of ERK1/2, JNK, and NF-κB in HUVECs, suggesting that IL-33 plays an important role in the pathophysiology and development of atherosclerosis. 28637660 2017