CXCL1, C-X-C motif chemokine ligand 1, 2919

N. diseases: 315; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE GRO alpha expression was evaluated in the tumour specimens compared with normal, while there was constitutive expression of GRO gamma in both normal and neoplastic colonic mucosa. 1341267 1992
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE Thus, GRO alpha is differently elevated in in vivo colon carcinoma specimens. 1341267 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE In the work described here we demonstrate that the clonal cell line Mel-a-6, produced by transfection of mouse Melan-a cells with human MGSA, had an increased ability to form large colonies in soft agar and increased ability to form tumors when injected into nude mice as compared to cells transfected with the neomycin resistance gene alone. 1861861 1991
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Melanoma cell lines were positive for MGSA protein in both the presence and the absence of serum. 2095366 1990
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.100 AlteredExpression phenotype BEFREE In contrast, MGSA mRNA was constitutively expressed in the absence of exogenous growth factors in cultures established from benign intradermal and dysplastic nevi and melanoma lesions in different stages of tumor progression. 2095366 1990
CUI: C0205748
Disease: Dysplastic Nevus
Dysplastic Nevus 		0.020 AlteredExpression disease BEFREE In contrast, MGSA mRNA was constitutively expressed in the absence of exogenous growth factors in cultures established from benign intradermal and dysplastic nevi and melanoma lesions in different stages of tumor progression. 2095366 1990
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE The level of MGSA mRNA in melanoma cells is strongly elevated by treatment with MGSA. 2970963 1988
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE We have previously shown that the NF-kappa B element at -83 to -65 is essential for basal and cytokine induced MGSA/GRO alpha promoter activity in the Hs294T melanoma and normal retinal pigment epithelial (RPE) cells, respectively. 7479086 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE We have characterized constitutive and cytokine-regulated MGSA/GRO alpha, -beta, and -gamma gene expression in normal retinal pigment epithelial (RPE) cells and a malignant melanoma cell line (Hs294T) to discern the mechanism for MGSA/GRO constitutive expression in melanoma. 8264646 1994
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Melanoma growth stimulatory activity (MGSA)/growth regulated (GRO) and interleukin-8 (IL-8) are highly related chemokines that have a causal role in melanoma progression. 8530498 1995
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.580 Biomarker disease BEFREE Biologically significant amounts of GRO are present in vivo in the bronchoalveolar lavage fluid of rabbits with E. coli pneumonia; by in situ hybridization, GRO mRNA is detectable in infiltrating pulmonary leukocytes and bronchial epithelial cells. 8631900 1996
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 Biomarker disease BEFREE In order to study the role of GRO cytokines in lung inflammation, we cloned the predominant rabbit GRO cDNA (RabGRO) from alveolar macrophages, expressed bioactive recombinant protein (rRabGRO) in Escherichia coli, and developed a sensitive and specific enzyme-linked immunosorbent assay for RabGRO protein. 8631900 1996
CUI: C0037772
Disease: Spastic Paraplegia
Spastic Paraplegia 		0.010 Biomarker disease BEFREE The definite genetic heterogeneity in FSP indicates that a multitude of genes/proteins can cause spastic paraplegia. 8782167 1996
CUI: C0021368
Disease: Inflammation
Inflammation 		0.220 Biomarker phenotype RGD Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. 8833037 1996
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.010 GeneticVariation disease BEFREE Three dominantly inherited "pure" form of familial spastic paraplegia (FSP) genes have been genetically mapped to regions of chromosomes, yet no specific genes or mutations have been identified (FSP1; chromosome 14q, FSP2; chromosome 2p and FSP3; chromosome 15q). 8874401 1996
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 AlteredExpression disease BEFREE Differential expression of GRO-alpha and IL-8 mRNA in psoriasis: a model for neutrophil migration and accumulation in vivo. 8875965 1996
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE The expression of the CXC chemokine MGSA is often deregulated during viral infection, chronic inflammation, and melanoma tumor progression. 9230219 1997
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.100 AlteredExpression phenotype BEFREE The expression of the CXC chemokine MGSA is often deregulated during viral infection, chronic inflammation, and melanoma tumor progression. 9230219 1997
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.030 AlteredExpression group BEFREE The expression of the CXC chemokine MGSA is often deregulated during viral infection, chronic inflammation, and melanoma tumor progression. 9230219 1997
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE The clones expressing the MGSA/GRO beta or -gamma transgene formed tumors within 2 months after injection; the tumors were highly pigmented and expressed immunoreactive MGSA/GRO beta or -gamma protein. 9334815 1997
CUI: C0374997
Disease: Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 		0.010 Biomarker disease BEFREE We examined secretion, mRNA expression, and histologic localization of interleukin-8 (IL-*) and growth-related gene product-alpha (GRO alpha) in the Helicobacter pylori-infected gastric antral mucosa. 9479649 1997
CUI: C0850666
Disease: Infection caused by Helicobacter pylori
Infection caused by Helicobacter pylori 		0.010 AlteredExpression disease BEFREE H pylori infection is associated with increased expression rates and production of C-X-C chemokines (IL-8 and GRO alpha), but not with increased production of C-C chemokines. 9659152 1998
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 Biomarker disease BEFREE GRO-alpha was significantly higher in RA than in OA and PT patients. 10229398 1999
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.030 Biomarker disease BEFREE GRO-alpha was significantly higher in RA than in OA and PT patients. 10229398 1999
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.210 Biomarker group RGD Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. 10498645 1999