|
Liver carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on the occurrence of alcohol induced liver cirrhosis and hepatocellular carcinoma (HCC).
|
24260493 |
2013 |
|
Septicemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The rs1429638 polymorphism in the CXCL1 gene and the rs2297630 polymorphism in the CXCL12 gene were associated with altered susceptibility to sepsis and might be used as important genetic markers to assess the risks of sepsis in trauma patients.
|
30489503 |
2019 |
|
Sepsis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The rs1429638 polymorphism in the CXCL1 gene and the rs2297630 polymorphism in the CXCL12 gene were associated with altered susceptibility to sepsis and might be used as important genetic markers to assess the risks of sepsis in trauma patients.
|
30489503 |
2019 |
|
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population.
|
15843053 |
2005 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this subnetwork, several receptors (EGFR, EGR1, ESR2, PGR), transcription factors (MYC, JAK), cytokines (IL8, IL6, IL1B), one chemokine (CXCL1), one kinase (SRC) and one cyclooxygenase (PTGS2) were described to be associated with inflammatory environment and steroid resistance in asthma.
|
27188427 |
2016 |
|
Hepatitis C
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In vitro carriers of the A allele produced greater amounts of CXCL1 in response to TLR2-ligands including HCV core and NS3, and HCV-infected carriers of the CXCL1 rs4074 A allele had higher CXCL1 serum levels than those with the G/G genotype.
|
22173151 |
2012 |
|
Liver Cirrhosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001).
|
24260493 |
2013 |
|
Liver Cirrhosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HCV-infected cirrhotic patients had a significantly greater CXCL1 rs4074 A allele frequency (43.3%) than patients without cirrhosis (32.7%, OR=1.573, p=0.03) and healthy controls (33.3%, OR=1.529, p=0.02).
|
22173151 |
2012 |
|
Liver Cirrhosis, Alcoholic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Distribution of the CXCL1 genotypes (GG/GA/AA) was 159/219/80 in patients with alcoholic cirrhosis, 52/44/19 in alcoholic controls and 158/140/44 in healthy controls.
|
24260493 |
2013 |
|
Cirrhosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001).
|
24260493 |
2013 |
|
Cirrhosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HCV-infected cirrhotic patients had a significantly greater CXCL1 rs4074 A allele frequency (43.3%) than patients without cirrhosis (32.7%, OR=1.573, p=0.03) and healthy controls (33.3%, OR=1.529, p=0.02).
|
22173151 |
2012 |
|
Alopecia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
|
26345899 |
2015 |
|
Alopecia Areata
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
|
26345899 |
2015 |
|
Liver diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Patients with alcohol-induced cirrhosis were significantly more often carriers of the CXCL1 rs4074 A allele (65.3%) than alcoholics without liver disease (54.8%, OR=1.55; 95%CI=1.025-2.350; p=0.04) and healthy controls (53.8%, OR=1.62; 95%CI=1.212-2.151; p=0.001).
|
24260493 |
2013 |
|
Reticuloendotheliosis, X-linked
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression levels of interleukin 6 (IL6), tumor growth factor B2 (TGFB2), vascular endothelial growth factor A (VEGFA), chemokine C-X-C motif ligand 1 (CXCL1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), glial fibrillary acidic protein (GFAP), and tenascin C (TNC) were significantly higher in eyes with iERM than in eyes with MH.
|
27736918 |
2016 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All together, these results suggest that DS may be a specific subgroup of schizophrenia with the characteristic abnormality of peripheral CXCL1 DNA methylation and gene expression.
|
30015110 |
2018 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CXCL1 gene and particularly T allele of rs3117604 was associated with IS.
|
23198952 |
2013 |
|
Familial (FPAH)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Three dominantly inherited "pure" form of familial spastic paraplegia (FSP) genes have been genetically mapped to regions of chromosomes, yet no specific genes or mutations have been identified (FSP1; chromosome 14q, FSP2; chromosome 2p and FSP3; chromosome 15q).
|
8874401 |
1996 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
RGD |
Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat.
|
20728373 |
2010 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury.
|
28935640 |
2018 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Thus, macrophage-FABP4 has a novel role in pulmonary host defense against P. aeruginosa infection by facilitating crosstalk between macrophages and neutrophils via regulation of macrophage CXCL1 production.-Liang, X., Gupta, K., Rojas Quintero, J., Cernadas, M., Kobzik, L., Christou, H., Pier, G. B., Owen, C. A., Çataltepe, S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.
|
30462529 |
2019 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia.
|
28381820 |
2017 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Biologically significant amounts of GRO are present in vivo in the bronchoalveolar lavage fluid of rabbits with E. coli pneumonia; by in situ hybridization, GRO mRNA is detectable in infiltrating pulmonary leukocytes and bronchial epithelial cells.
|
8631900 |
1996 |
|
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2.
|
26747783 |
2016 |