Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
We further show that loss of heterozygosity of the APC gene in tumors from carriers of the APC*E1317Q mutation may involve the mutated allele, not just the wild-type allele, suggesting the APC*E1317Q missense mutation may not be pathologically significant in the development of colorectal tumors.
|
23846443 |
2013 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
|
8187091 |
1994 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
TNIK inhibition abrogates colorectal cancer stemness.
|
27562646 |
2016 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Consequently, loss or mutation of the APC gene causes colorectal tumors in humans and mice.
|
21366352 |
2011 |
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
BEFREE |
Then we used these assays for the analysis of MGMT and APC promoter methylation in a subset of archival formalin-fixed paraffin-embedded colorectal tumor specimens.
|
19179456 |
2009 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
|
20707908 |
2010 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Distinct genetic abnormalities (loss-of-function mutations of APC and p53 and oncogenic activation of Ki-ras) are associated with specific stages of the sporadic, most common types of colorectal tumors.
|
9541486 |
1998 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.
|
24518971 |
2014 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
APC and KRAS were mutated at significantly lower rates in tumors from patients with IBD than in sporadic colorectal tumors (13% and 20% of cases, respectively).
|
26764183 |
2016 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population.
|
17854661 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms.
|
15959913 |
2005 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers?
|
17653897 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene (chromosome 5q21).
|
11867715 |
2002 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Most mutated APC proteins in colorectal tumors lack the beta-catenin-binding regions and fail to inhibit Wnt signaling, leading to the overproliferation of tumor cells.
|
17572842 |
2007 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors.
|
1310068 |
1992 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.
|
24651453 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
"APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."
|
10737795 |
2000 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer.
|
11668620 |
2001 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
|
12907644 |
2003 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
|
21967605 |
2011 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The proband had a severe microsatellite instability (MIN) phenotype in both tumor and normal colon mucosa, and mutations in the TGFbeta-RII and APC genes in the colorectal tumor.
|
10763829 |
2000 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract.
|
24416237 |
2014 |