Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
We further show that loss of heterozygosity of the APC gene in tumors from carriers of the APC*E1317Q mutation may involve the mutated allele, not just the wild-type allele, suggesting the APC*E1317Q missense mutation may not be pathologically significant in the development of colorectal tumors.
|
23846443 |
2013 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
|
8187091 |
1994 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Consequently, loss or mutation of the APC gene causes colorectal tumors in humans and mice.
|
21366352 |
2011 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Distinct genetic abnormalities (loss-of-function mutations of APC and p53 and oncogenic activation of Ki-ras) are associated with specific stages of the sporadic, most common types of colorectal tumors.
|
9541486 |
1998 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.
|
24518971 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population.
|
17854661 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The authors evaluated the frequency of the carrier status of three ancestral colorectal neoplasm-associated mutations (APC:I1307K, BLM(Ash), and MSH2*1906G>C) found in the Jewish population among a case series with documented colorectal neoplasms.
|
15959913 |
2005 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers?
|
17653897 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene (chromosome 5q21).
|
11867715 |
2002 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.
|
24651453 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
"APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."
|
10737795 |
2000 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer.
|
11668620 |
2001 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The proband had a severe microsatellite instability (MIN) phenotype in both tumor and normal colon mucosa, and mutations in the TGFbeta-RII and APC genes in the colorectal tumor.
|
10763829 |
2000 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients.
|
21901162 |
2011 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients.
|
15040027 |
2004 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that a mutation of the APC gene may play an important role in the genesis of sporadic hepatoblastomas, and the mechanisms of APC gene alteration may be different from those reported previously for colorectal tumors.
|
8764128 |
1996 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
|
17704924 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
|
15943410 |
2005 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors.
|
1338904 |
1992 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Thus the mutations of the APC gene may have a major role in the early development of sporadic colorectal tumors.
|
9083931 |
1997 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |