|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
UNIPROT |
|
|
|
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors.
|
1310068 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors.
|
1338904 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
|
1338904 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These data provide strong evidence that mutations of the APC gene play a major role in the early development of colorectal neoplasms.
|
1528264 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
APC mutations occur early during colorectal tumorigenesis.
|
1528264 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.
|
1541640 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
[The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants].
|
2281069 |
1990 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms.
|
7923190 |
1994 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
|
8187091 |
1994 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients.
|
8385345 |
1993 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Germline mutations of the APC gene are responsible for familial adenomatous polyposis, an autosomal dominant inherited predisposition to colorectal tumors.
|
8389242 |
1993 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved.
|
8609698 |
1996 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The prominent role of the APC gene in colorectal tumor development is well established.
|
8649856 |
1996 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that a mutation of the APC gene may play an important role in the genesis of sporadic hepatoblastomas, and the mechanisms of APC gene alteration may be different from those reported previously for colorectal tumors.
|
8764128 |
1996 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The protein products of mutant APC genes present in colorectal tumors were found to be defective in this activity.
|
9065402 |
1997 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Thus the mutations of the APC gene may have a major role in the early development of sporadic colorectal tumors.
|
9083931 |
1997 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
A number of other tumor suppressor genes, APC gene, p53, and DCC have also been implicated in colorectal tumor carcigenesis.
|
9422268 |
1997 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Since the alteration of the APC gene occurs early in most colorectal tumors, the detection of APC mutations in fecal tumor DNA by HD-PCR may be a powerful tool in non-invasive cancer diagnostics.
|
9450908 |
1998 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Although mutation of the APC gene is an integral component of sporadic colorectal carcinogenesis, alteration in the region including the MOM gene does not appear to play a significant role in the development or clinicopathologic behavior of human sporadic colorectal tumors.
|
9527272 |
1998 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Distinct genetic abnormalities (loss-of-function mutations of APC and p53 and oncogenic activation of Ki-ras) are associated with specific stages of the sporadic, most common types of colorectal tumors.
|
9541486 |
1998 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Recently, however, a missense variant of APC (I1307K) was described that confers an increased risk of colorectal tumors, including multiple adenomas, in Ashkenazim.
|
9724771 |
1998 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
These findings support a model where somatic instability of the (A)8 tract produced by the APC I1307K allele leads to increased APC gene inactivation and directly accounts for 42% of the colorectal neoplasms occurring in APC I1307K carriers.
|
9751605 |
1998 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Mutations in the adenomatous polyposis coli (APC) gene are linked to the dysplastic transformation of colorectal polyps and represent an early step in the development of colorectal tumors.
|
10188731 |
1999 |
|
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Turcot's syndrome is characterized clinically by the occurrence of primary brain tumor and colorectal tumor and has in previous reports been shown to be associated with germline mutations in the genes APC, hMLH1, and hPMS2.
|
10337989 |
1999 |