|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings explain, for example, the efficacy of estrogen therapy or 5-HT uptake blockers such as fluoxetine in treating the depressive symptoms of the premenstrual syndrome. and suggest that the sex differences in schizophrenia may also be due to an action of estrogen mediated by way of 5-HT2A receptors.3.
|
8818400 |
1996 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These data did not provide evidence for a contribution of the 102T/C SNP of HTR2A gene to susceptibility to the southern Han Chinese schizophrenia.
|
15048642 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data did not provide evidence for a contribution of the 102T/C SNP of HTR2A gene to susceptibility to the southern Han Chinese schizophrenia.
|
15048642 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There was no genetic association between HTR2A T102C with either schizophrenia or bipolar disorder under the assumption of a parent-of-origin effect, and these data together essentially exclude imprinting at this locus as a potential explanation for the complex inheritance observed in major psychoses.
|
17407792 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
There actually exists significant implication of CYP2D6 genetic polymorphisms on the metabolic kinetics of risperidone, little is known about the extent of CYP2D6 impacting human D2 and 5-HT2A receptor occupancies as well as the clinical efficacy and efficacy in schizophrenia treatment.
|
30281999 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behaviour by a genetic association between the 5-HT2A T102C silent polymorphism and suicidality in patients with mood disorders and schizophrenia.
|
18783799 |
2009 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-HT2AR and/or 5-HT2CR are implicated in neuropsychiatric disorders (e.g., addiction, obesity, schizophrenia).
|
30157263 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that variability in the 5-HT2A gene may influence emotion management in patients with schizophrenia.
|
19913072 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the human HTR2 MspI polymorphism might not be associated with a risk factor for developing alcohol dependence or susceptibility to schizophrenia.
|
10754425 |
2000 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in our Brazilian sample.
|
17420819 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results of this study did not demonstrate a robust association of the allele C of the T102C HTR2A polymorphism with lifetime or current suicidality in patients with schizophrenia.
|
15469201 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The results of the present study seem to indicate that HTR2A gene polymorphism influences the tendency to express TD following prolonged antipsychotic drug exposure in Turkish schizophrenia patients.
|
17688403 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study seem to indicate that HTR2A gene polymorphism influences the tendency to express TD following prolonged antipsychotic drug exposure in Turkish schizophrenia patients.
|
17688403 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The putative role of epigenetic factors is shown by the epigenetic interpretation of genetic association studies of the genes for serotonin 2A (HTR2A) and the dopamine D3 (DRD3) receptors in schizophrenia.
|
10869881 |
2000 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosomes 13.
|
8678105 |
1996 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interaction of many neuroleptics and antidepressants with 5-HT2A receptors points up the potential importance of this receptor for understanding and treating neuropsychiatric disorders such as schizophrenia and depression.
|
9928234 |
1998 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The inbred Roman High- (RHA-I) and Low- (RLA-I) Avoidance rat strains are a congenital neurobehavioral model, with the RHA-I displaying schizophrenia-related behaviors and serotonin 2A (5-HT2A) and metabotropic glutamate 2 (mGlu2) receptor alterations in the prefrontal cortex (PFC).
|
31228641 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The impact of HTR2C and HTR2A polymorphisms on body mass index (BMI), glucose-insulin homeostasis, and blood lipid levels was evaluated in 46 patients with schizophrenia or schizoaffective disorder and treated with olanzapine (n = 28) or clozapine (n = 18) for at least 6 months.
|
19142110 |
2009 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
RGD |
The genetic association database.
|
15118671 |
2004 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The effects of hallucinogenic drugs, such as psilocybin and lysergic acid diethylamide, require the 2AR and resemble some of the core symptoms of schizophrenia.
|
18297054 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The authors examined the frequencies of gene polymorphisms in the 5-HT1A (Arg219Leu) and 5-HT2A (Thr25Asn and His452Tyr) receptor genes in 29 patients previously diagnosed with neuroleptic malignant syndrome, 94 neuroleptic-treated patients with schizophrenia who had no history of neuroleptic malignant syndrome, and 94 healthy comparison subjects.
|
9734554 |
1998 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in DRD2 and 5-HT2 receptor genes are associated with schizophrenia in North Indian population.
|
30389402 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population.
|
27756686 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia.
|
21912188 |
2011 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment.
|
15383158 |
2004 |