|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that IL6 promoter genotypes associated with altered gene expression are risk factors for development of KS.
|
11001912 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model.
|
30265712 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients.
|
15154666 |
2004 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormal expression of the IL-6 gene has been suggested to be involved in the pathogenesis of a variety of diseases, especially rheumatoid arthritis, Castleman's disease, mesangial proliferative glomerulonephritis, multiple myeloma and Kaposi's sarcoma.
|
1643291 |
1992 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
|
10361100 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
|
21984125 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.
|
10364379 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6.
|
10779772 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome."
|
30541844 |
2019 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
J Virol 1997;71:4187-4192; Nicholas J, Ruvolo VR, Burns WH, Sandford G, Wan X, Ciufo D, Hendrickson SB, Guo HG, Hayward GS, Reitz MS. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.
|
10738139 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08).
|
29381560 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases.
|
10861641 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue.
|
11274637 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
|
17483315 |
2007 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.
|
27166260 |
2016 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.
|
21767154 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells.
|
10628804 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3.
|
31801855 |
2020 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease.
|
11172301 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preincubation with recombinant human IL-6 or OSM sensitized KS in a dose dependent manner.
|
11380243 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease.
|
24198402 |
2014 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions.
|
8939871 |
1996 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
|
11264189 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-4, a cytokine with pleiotropic effects, suppresses IL-6 in vivo and modestly inhibits AIDS-KS-derived cells in vitro.
|
12513914 |
2002 |